2'-Methyl-5'-(trifluoromethyl)spiro[cyclohexane-1,1'-isoindoline]-3',4-dione CAS 2377418-05-6
| CAS No. | 2377418-05-6 |
| Molecular Formula | C15H14F3NO2 |
| Molecular Weight | 297.27 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
2'-Methyl-5'-(trifluoromethyl)spiro[cyclohexane-1,1'-isoindoline]-3',4-dione (CAS 2377418-05-6), molecular formula C15H14F3NO2 and molecular weight 297.27 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2'-Methyl-5'-(trifluoromethyl)spiro[cyclohexane-1,1'-isoindoline]-3',4-dione (C15H14F3NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C15H14F3NO2 |
| Molecular Weight | 297.27 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
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- 2,6-Dibromo-4-chloro-3-fluoroaniline (CAS 1160574-58-2)
- 1-(1h-Imidazol-2-yl)ethan-1-amine hydrochloride (CAS 1422344-48-6)
- Elagolix Impurity 55 (CAS CATO-C4X-206855)
- 2,6-Di(tert-butyl)-4-nitrosophenol (CAS 955-03-3)
- 2-(Aminomethyl)-5-(difluoromethyl)-4-(trifluoromethoxy)pyridine-3-methanol (CAS 1806760-43-9)
- Ceftriaxone Impurity 27 (CAS CATO-C4X-116327)
- 2,5-Dimethyl-1-octadecyl-1H-pyrrole (CAS 102809-09-6)
- tert-Butyl 2-aminopent-4-ynoate (CAS 754141-33-8)
- Eosinophilotactic Peptide (CAS 61756-28-3)
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