4-(Ethoxycarbonyl)-2,6-difluorophenylboronic acid CAS 2377605-88-2
| CAS No. | 2377605-88-2 |
| Molecular Formula | C9H9BF2O4 |
| Molecular Weight | 229.97 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
4-(Ethoxycarbonyl)-2,6-difluorophenylboronic acid (CAS 2377605-88-2) is a high-purity analytical reference standard with the molecular formula C9H9BF2O4 and a molecular weight of 229.97 g/mol.
The molecular framework of 4-(Ethoxycarbonyl)-2,6-difluorophenylboronic acid (C9H9BF2O4) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), 4-(Ethoxycarbonyl)-2,6-difluorophenylboronic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H9BF2O4 |
| Molecular Weight | 229.97 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | F-containing |
Related Ethoxycarbonyl Standards
- (2,2-Bis(ethoxycarbonyl)cyclopropyl)boronic acid (CAS 2225152-08-7)
- 2-(Ethoxycarbonyl)-4,5-difluorobenzoic acid (CAS 1565354-74-6)
- 3,4-Bis(ethoxycarbonyl)-1,2,5-oxadiazole 2-oxide (CAS 18417-40-8)
- 2-(Ethoxycarbonyl)-6-fluorospiro[3.3]heptane-2-carboxylic acid (CAS 2715243-00-6)
- {2-[(Ethoxycarbonyl)amino]-1,3-thiazol-4-yl}acetic Acid (CAS 887576-08-1)
- 5-((Ethoxycarbonyl)amino)-3-methylisothiazole-4-carboxylic acid (CAS 22131-50-6)
- 3-(4-(Ethoxycarbonyl)piperazin-1-yl)propanoic acid (CAS 1154239-08-3)
- 2-(4-(Ethoxycarbonyl)piperazin-1-yl)propanoic acid (CAS 1250888-43-7)
Recommended Standards
- [2-fluoro-4-(trifluoromethoxy)phenyl]boronic acid (CAS 503309-10-2)
- 5-(bromomethyl)-3-(trifluoromethyl)isoxazole (CAS 1364677-98-4)
- (4-(1,3-Dioxolan-2-yl)-2,6-difluorophenyl)boronic acid (CAS 1072946-41-8)
- 5-(Bromomethyl)-2-(trifluoromethyl)oxazole (CAS 157984-74-2)
- N-(2-((3-cyano-4,6-dimethylpyridin-2-yl)thio)phenyl)-4-fluorobenzamide (CAS 478045-71-5)
- 3-Chloroisonicotinaldehyde hydrochloride (CAS 1826110-00-2)
- 4-Amino-1-methyl-1h-pyrrole-2-carboxylic acid (CAS 45776-13-4)
- (S)-4-[4-(Oxiranylmethoxy)-1,2,5-thiadiazol-3-yl]morpholine (CAS 69500-53-4)
- 2-(4-Biphenylyl)imidazole (CAS 92437-07-5)
- Alogliptin impurity 75 (CAS 1638544-55-4)
- (R)-4-methylcyclohex-3-ene-1-carboxylic acid (CAS 121424-36-0)
- Tert-butyl n-[1-(hydroxymethyl)cyclopentyl]carbamate (CAS 168540-07-6)
- 2-(5-Chlorobenzofuran-2-yl)propanoic acid (CAS 1541056-66-9)
- Semaglutide impurity 215 (CAS CATO-C4X-2226215)
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