6-Bromo-3-t-butyldimethylsilyloxy-2-fluorophenylboronic acid CAS 2377608-15-4
| CAS No. | 2377608-15-4 |
| Molecular Formula | C12H19BBrFO3Si |
| Molecular Weight | 349.08 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 6-Bromo-3-t-butyldimethylsilyloxy-2-fluorophenylboronic acid.
6-Bromo-3-t-butyldimethylsilyloxy-2-fluorophenylboronic acid (CAS 2377608-15-4) is a high-purity analytical reference standard with the molecular formula C12H19BBrFO3Si and a molecular weight of 349.08 g/mol.
Structurally, 6-Bromo-3-t-butyldimethylsilyloxy-2-fluorophenylboronic acid (C12H19BBrFO3Si) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 2.5, corresponding to approximately 2 ring(s) or double-bond equivalent(s). With a molecular weight of 349.08 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H19BBrFO3Si |
| Molecular Weight | 349.08 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.5 |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | F/Br-containing |
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