4-Carboxy-3,5-difluoro-2-nitrophenylboronic acid CAS 2377611-44-2
| CAS No. | 2377611-44-2 |
| Molecular Formula | C7H4BF2NO6 |
| Molecular Weight | 246.92 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Carboxy-3,5-difluoro-2-nitrophenylboronic acid.
4-Carboxy-3,5-difluoro-2-nitrophenylboronic acid (CAS 2377611-44-2), molecular formula C7H4BF2NO6 and molecular weight 246.92 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a carbohydrate-derived structure, an amide group, fluorine substitution, 4-Carboxy-3,5-difluoro-2-nitrophenylboronic acid is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 246.92 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 4-Carboxy-3,5-difluoro-2-nitrophenylboronic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C7H4BF2NO6 |
| Molecular Weight | 246.92 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
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- 1,2,3,4-tetrahydroquinolin-7-ylmethanol (CAS 1000045-81-7)
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- 5-(Difluoromethyl)-2,3-difluoropyridine (CAS 1804659-36-6)
- 2-((3,4-Dichlorobenzyl)thio)-3-methyl-6-(trifluoromethyl)pyrimidin-4(3H)-one (CAS 344282-91-3)
- (2E)-2-(Benzenesulfonyl)-3-{2-[(4-chlorophenyl)sulfanyl]-5-nitrophenyl}prop-2-enenitrile (CAS 1025642-11-8)
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- 3-Difluoromethyl-5-(trifluoromethyl)benzonitrile (CAS 1803825-95-7)
- 57479-70-6 7-[(E)-2-ethylhex-1-enyl]-8-quinolinol 7-[(E)-2-ethylhex-1-enyl]quinolin-8-ol A831458 (CAS 57479-70-6)
- 2-Cyclopropyl-5-((3,5-dimethylbenzyl)oxy)benzofuran-3-carbaldehyde (CAS 1210670-18-0)
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