Benzyl (3R,4S)-3-hydroxy-4-isobutylpyrrolidine-1-carboxylate CAS 2377786-89-3
| CAS No. | 2377786-89-3 |
| Molecular Formula | C16H23NO3 |
| Molecular Weight | 277.36 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Benzyl (3R,4S)-3-hydroxy-4-isobutylpyrrolidine-1-carboxylate.
Benzyl (3R,4S)-3-hydroxy-4-isobutylpyrrolidine-1-carboxylate (CAS 2377786-89-3) is a high-purity analytical reference standard with the molecular formula C16H23NO3 and a molecular weight of 277.36 g/mol.
The molecular framework of Benzyl (3R,4S)-3-hydroxy-4-isobutylpyrrolidine-1-carboxylate (C16H23NO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Benzyl (3R,4S)-3-hydroxy-4-isobutylpyrrolidine-1-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H23NO3 |
| Molecular Weight | 277.36 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Nitrogen Atoms | 1 |
Recommended Standards
- Benzyl (2R,5R)-2-(hydroxymethyl)-5-propylpyrrolidine-1-carboxylate (CAS 2304457-14-3)
- Benzyl (3S,4R)-3-hydroxy-4-isobutylpyrrolidine-1-carboxylate (CAS 2377786-88-2)
- Acetamidoeugenol (CAS 305-13-5)
- benzyl (R)-(1-cyclohexyl-2-hydroxyethyl)carbamate (CAS 200405-29-4)
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