2-Chloro-4-ethoxy-5-fluorobenzoic acid CAS 2384803-60-3
| CAS No. | 2384803-60-3 |
| Molecular Formula | C9H8ClFO3 |
| Molecular Weight | 218.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-Chloro-4-ethoxy-5-fluorobenzoic acid (C9H8ClFO3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
2-Chloro-4-ethoxy-5-fluorobenzoic acid (CAS 2384803-60-3), molecular formula C9H8ClFO3 and molecular weight 218.61 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Chloro-4-ethoxy-5-fluorobenzoic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H8ClFO3 |
| Molecular Weight | 218.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 2-(3-Chloro-5-fluoro-4-methoxyphenyl)acetic acid (CAS 1000544-65-9)
- 2-(2-Chloro-6-fluoro-3-methoxyphenyl)acetic acid (CAS 1017777-68-2)
- 6-Chloro-2-fluoro-3-methoxyphenylacetic acid (CAS 1017777-83-1)
- 3-Chloro-4-ethoxy-5-fluorobenzoic acid (CAS 1017778-72-1)
- 3-(2-Chloro-6-fluorophenyl)-2-hydroxypropanoic acid (CAS 1181561-52-3)
- Methyl 2-(4-chloro-3-fluorophenyl)-2-hydroxyacetate (CAS 1248821-36-4)
- 3-(2-Chloro-6-fluorophenyl)-3-hydroxypropanoic acid (CAS 1249515-00-1)
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Recommended Standards
- 2-Chloro-3-ethoxy-6-fluorobenzoic acid (CAS 2384893-59-6)
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- 2-(3-Chloro-4-fluorophenoxy)propanoic acid (CAS 847867-08-7)
- 2-Chloro-5-fluoro-3,4-dimethoxybenzaldehyde (CAS 2645992-51-2)
- Methyl 4-(3-fluorophenyl)-3-oxo-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine-7-carboxylate (CAS 1708288-77-0)
- Ethyl 6-Hydroxyimidazo[1,2-a]pyridine-2-carboxylate (CAS 1254170-86-9)
- 4-(2-Ethylphenoxy)aniline (CAS 383126-80-5)
- N-(2-((3-(3-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)oxy)ethyl)-3,5-dimethylisoxazole-4-sulfonamide (CAS 1203415-31-9)
- 3-(Benzofuran-2-yl)-6-(tert-butyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole (CAS 1707563-55-0)
- 4-(4-Methyl-piperidin-1-yl)-benzonitrile (CAS 85872-87-3)
- 2-(3,4-Dimethoxyphenyl)-N-(pyridin-2-ylmethyl)ethan-1-amine (CAS 99615-36-8)
- (4-Iodo-2-methyl-phenoxy)-acetic acid ethyl ester (CAS 636589-61-2)
- 2,4-Dimethyl-6-(morpholinomethyl)phenol hydrochloride (CAS 1052543-29-9)
- GnRH Associated Peptide (GAP) (1-13), human (CAS 100111-07-7)
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