5-Chloro-2-hydroxy-4-(trifluoromethyl)benzoic acid CAS 2386287-27-8
| CAS No. | 2386287-27-8 |
| Molecular Formula | C8H4ClF3O3 |
| Molecular Weight | 240.56 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5-Chloro-2-hydroxy-4-(trifluoromethyl)benzoic acid (C8H4ClF3O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
5-Chloro-2-hydroxy-4-(trifluoromethyl)benzoic acid (CAS 2386287-27-8), molecular formula C8H4ClF3O3 and molecular weight 240.56 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-Chloro-2-hydroxy-4-(trifluoromethyl)benzoic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H4ClF3O3 |
| Molecular Weight | 240.56 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 2-Chloro-3-(trifluoromethoxy)benzoic acid (CAS 1036204-41-7)
- 4-Chloro-2-(trifluoromethoxy)benzoic acid (CAS 1261605-70-2)
- 2-Chloro-6-(trifluoromethoxy)benzoic acid (CAS 1261617-84-8)
- 2-Chloro-4-(trifluoromethoxy)benzoic acid (CAS 1261731-19-4)
- 3-Chloro-2-(trifluoromethoxy)benzoic acid (CAS 1261822-68-7)
- 2-Chloro-5-(trifluoromethoxy)benzoic acid (CAS 1261836-04-7)
- 3-Chloro-4-(trifluoromethoxy)benzoic Acid (CAS 158580-93-9)
- 3-Chloro-5-(trifluoromethoxy)benzoic acid (CAS 433926-46-6)
Recommended Standards
- 5-Chloro-2-(trifluoromethoxy)benzoic acid (CAS 959749-82-7)
- 2-(Chloromethyl)-3-nitro-5-(trifluoromethyl)pyridine (CAS 1227574-03-9)
- 4-Chloro-3-(trifluoromethoxy)benzoic acid (CAS 886500-50-1)
- Methyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate (CAS 1393576-33-4)
- FAM alkyne, 6-isomer (CAS 478801-49-9)
- n-Benzyl-5-chloropyrimidin-2-amine (CAS 856974-03-3)
- Oleanolic Acid Impurity 2 (3-O-p-Coumaroyloleanolic Acid) (CAS 151334-06-4)
- N-(5-Amino-2-methylphenyl)-2-chlorobenzamide (CAS 436089-22-4)
- Tranylcypromine Impurity 2 (CAS 17364-52-2)
- SERVA Blue W soluble in water (CAS 5863-46-7)
- 3-((2-Fluorobenzyl)thio)-6-(4-fluorophenyl)pyridazine (CAS 872695-02-8)
- 1-(2-Chlorophenyl)-4-(furan-2-ylmethyl)piperazine (CAS 53018-26-1)
- (6,7-Dihydro-[1,4]dioxino[2,3-d]pyrimidin-2-yl)methanol (CAS 946505-93-7)
- Protein Kinase C (19-36) Peptide (CAS 113731-96-7)
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