4-Hydroxy-benzoic acid 2,2,3,3-tetrafluoro-propyl ester CAS 238751-63-8
| CAS No. | 238751-63-8 |
| Molecular Formula | C10H8F4O3 |
| Molecular Weight | 252.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 252.16 g/mol gives 4-Hydroxy-benzoic acid 2,2,3,3-tetrafluoro-propyl ester distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
4-Hydroxy-benzoic acid 2,2,3,3-tetrafluoro-propyl ester (CAS 238751-63-8) is a high-purity analytical reference standard with the molecular formula C10H8F4O3 and a molecular weight of 252.16 g/mol.
The molecular framework of 4-Hydroxy-benzoic acid 2,2,3,3-tetrafluoro-propyl ester (C10H8F4O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Hydroxy-benzoic acid 2,2,3,3-tetrafluoro-propyl ester meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H8F4O3 |
| Molecular Weight | 252.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
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Recommended Standards
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- 4,4,5,5-Tetramethyl-2-(7-oxaspiro[3.5]nonan-2-yl)-1,3,2-dioxaborolane (CAS 2706615-22-5)
- 7-(tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-a]pyridine (CAS 908268-52-0)
- 6-Bromo-1-oxo-indan-4-carboxylic acid (CAS 866848-85-3)
- 5-(2-Anilinovinyl)-3-(2,6-dichlorophenyl)-4-isoxazolecarbonitrile (CAS 338394-19-7)
- 2-Chloro-1-[chloro(difluoro)methoxy]-4-(trifluoromethyl)benzene (CAS 1417567-86-2)
- (R)-3-Fluoro-4-methyl-1,4-pentanediol (CAS 86677-75-0)
- N-(2,3-Dimethylphenyl)-4-nitrobenzenesulfonamide (CAS 296274-30-1)
- n-(2-(1h-Pyrazol-1-yl)ethyl)-1-(3-chlorophenyl)ethan-1-amine (CAS 1308211-65-5)
- 3-propylbenzaldehyde (CAS 103528-31-0)
- 4-Chloro-1-ethyl-3,5-dimethyl-1H-pyrazole (CAS 1171799-90-8)
- 5,7-Difluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-indole (CAS 1878207-49-8)
- Liraglutide-d8 Tetratrifluoroacetate (CAS 204656-20-2 (non-labelled, free base))
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