2-(Bromomethyl)-2-(4-fluorophenyl)-1,3-dioxolane CAS 24169-37-7
| CAS No. | 24169-37-7 |
| Molecular Formula | C10H10BrFO2 |
| Molecular Weight | 261.09 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 2-(Bromomethyl)-2-(4-fluorophenyl)-1,3-dioxolane (CAS 24169-37-7), a certified reference material (molecular formula C10H10BrFO2, MW 261.09 g/mol) for analytical method development and quality control.
The molecular framework of 2-(Bromomethyl)-2-(4-fluorophenyl)-1,3-dioxolane (C10H10BrFO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H10BrFO2 |
| Molecular Weight | 261.09 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | F/Br-containing |
Related Bromomethyl Standards
- Ethyl 3-(bromomethyl)-2-fluorobenzoate (CAS 1006619-22-2)
- Ethyl 3-(bromomethyl)-4-fluorobenzoate (CAS 347852-71-5)
- Ethyl 4-(bromomethyl)-3-fluorobenzoate (CAS 86239-01-2)
- Methyl 2-(3-(bromomethyl)-5-fluorophenyl)acetate (CAS 1980044-80-1)
- Methyl 5-(bromomethyl)-2-fluorophenylacetate (CAS 677775-73-4)
- 1-(Bromomethyl)-1-(2,2,2-trifluoroethoxy)cyclopentane (CAS 1248296-99-2)
- 1-(Bromomethyl)-3-(trifluoromethoxy)cyclohexane (CAS 2231675-08-2)
- 1-(Bromomethyl)-4-(trifluoromethoxy)cyclohexane (CAS 2167441-51-0)
Recommended Standards
- 2-(6-Bromo-2-fluoro-3-methylphenyl)-1,3-dioxolane (CAS 2221812-38-8)
- 2-Bromo-1-(3-fluoro-4-methoxyphenyl)propan-1-one (CAS 4467-08-7)
- 2-(5-Bromo-2-fluoro-3-methylphenyl)-1,3-dioxolane (CAS 2221812-06-0)
- 2-Bromo-6-fluoro-3-isopropoxybenzaldehyde (CAS 2624417-41-8)
- [1,3-Bis[2,6-bis[bis(4-methylphenyl)methyl]-4-methylphenyl]-1,3-dihydro-2H-imidazol-2-ylidene]hydroxygold-HF (CAS 1690356-94-5)
- 1-(1-Azepanyl)-2-fluoroethanone (CAS 769-75-5)
- 6-Amino-3-benzylquinazolin-4(3H)-one (CAS 591755-14-5)
- (S)-4-(2,7-dichloropyrido[2,3-d]pyrimidin-4-yl)-3-methylmorpholine (CAS 1009303-42-7)
- [3-Fluoro-2-(trifluoromethyl)pyridin-4-yl]methanol (CAS 1227600-70-5)
- 1-Hydroxyhexan-2-one (CAS 73397-68-9)
- bis(1H-pyrrol-2-yl)methanone (CAS 15770-21-5)
- Ticagrelor Impurity 168 (CAS 1207276-00-3(free base))
- 2,6-Dimethyl-3,5-Diethoxycarbonyl-4-(O-Difluoromethylsulfonylphenyl)-1,4-Dihydropyridine (CAS 84761-75-1)
- Insulin Degludec Impurity 28 (CAS CATO-C4X-215728)
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