4,5-Dichloro-2,6-difluoropyrimidine CAS 24178-72-1

Purity 97%+In StockPharmaceutical Standards
CAS No.24178-72-1
Molecular FormulaC4Cl2F2N2
Molecular Weight184.96 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

4,5-Dichloro-2,6-difluoropyrimidine CAS 24178-72-1 chemical structure

Description

Compared with other compounds in its class, the molecular weight of 184.96 g/mol gives 4,5-Dichloro-2,6-difluoropyrimidine distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

4,5-Dichloro-2,6-difluoropyrimidine (CAS 24178-72-1), molecular formula C4Cl2F2N2 and molecular weight 184.96 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of 4,5-Dichloro-2,6-difluoropyrimidine (C4Cl2F2N2) is characterized by a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 4,5-Dichloro-2,6-difluoropyrimidine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC4Cl2F2N2
Molecular Weight184.96 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)4.0
UV AbsorptionUV-absorbing
CAS Registry Year (est.)1963
Halogen ContentF/Cl-containing
Nitrogen Atoms2

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