4-(3-Chlorophenyl)-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-5-amine CAS 242797-30-4
| CAS No. | 242797-30-4 |
| Molecular Formula | C16H11ClF3N3 |
| Molecular Weight | 337.73 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 4-(3-Chlorophenyl)-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-5-amine (C16H11ClF3N3) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
4-(3-Chlorophenyl)-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-5-amine (CAS 242797-30-4) is a high-purity analytical reference standard with the molecular formula C16H11ClF3N3 and a molecular weight of 337.73 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H11ClF3N3 |
| Molecular Weight | 337.73 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Chlorophenyl Standards
- 1-(3-Chlorophenyl)-4-(3-(trifluoromethyl)phenyl)-1H-pyrazol-5-amine (CAS 324008-97-1)
- 4-(4-Chlorophenyl)-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-5-amine (CAS 324008-99-3)
- 1-(4-Chlorophenyl)-1H-pyrido[2,3-e][1,3,4]thiadiazine-3-carboxylic acid 4,4-dioxide (CAS 1774901-24-4)
- 3-(4-Chlorophenyl)-5-[(tetrahydro-2H-pyran-2-yloxy)methyl]isoxazole-4-carboxylic acid (CAS 1242926-34-6)
- 3-((3-Chlorophenyl)sulfonyl)-8-fluoroquinolin-4(1H)-one (CAS 1779131-80-4)
- 3-[(4-Chlorophenyl)[(2-tetrahydropyranyl)oxy]methyl]isoxazole-4-carboxylic Acid (CAS 2006277-13-8)
- Ethyl 3-((4-chlorophenyl)amino)-2-(2,5-dioxotetrahydrofuran-3-yl)but-2-enoate (CAS 216876-53-8)
- 1-{4-[(2E)-3-(2-Chlorophenyl)prop-2-enoyl]phenyl}-1H-pyrrole-2,5-dione (CAS 1365988-75-5)
Recommended Standards
- 2-(4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)acetohydrazide (CAS 338979-10-5)
- 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N1,N1,N3,N3-tetramethylmalonamide (CAS 338406-79-4)
- 7-Chloro-N-(2-(trifluoromethyl)benzyl)quinazolin-4-amine (CAS 477861-90-8)
- 7-Chloro-N-{[3-(trifluoromethyl)phenyl]methyl}quinazolin-4-amine (CAS 477861-91-9)
- 3-bromo-8-methyl-naphthalene-1-carboxylic acid (CAS 2387596-05-4)
- 3-(2-Naphthyl)-L-alanine hydrochloride, 97% (CAS 122745-12-4)
- 5-Amino-2,4-difluoro-n-methoxybenzamide (CAS 658085-51-9)
- tert-butyl 2-(3-hydroxyazetidin-1-yl)acetate (CAS 1272955-38-0)
- n-(2-Chloro-6-fluorobenzyl)-3-methylbutan-1-amine (CAS 931991-26-3)
- 5-Allyl-1-butoxy-2,3-difluorobenzene (CAS 1443355-00-7)
- 2-(difluoromethoxy)-N-methoxy-N-methylbenzamide (CAS 1275755-34-4)
- 2-(2-(Trifluoromethyl)phenyl)azepane (CAS 527673-77-4)
- 4-(4,6-Dimethoxypyrimidin-2-yl)benzoic acid (CAS 386715-40-8)
- Des-Gly29,30-Tirzepatide (CAS CATO-CPTD788944)
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