N-(2-benzoyl-4-chlorophenyl)thiophene-2-carboxamide CAS 24341-74-0
| CAS No. | 24341-74-0 |
| Molecular Formula | C18H12ClNO2S |
| Molecular Weight | 341.81 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-(2-benzoyl-4-chlorophenyl)thiophene-2-carboxamide.
CATO supplies N-(2-benzoyl-4-chlorophenyl)thiophene-2-carboxamide (CAS 24341-74-0), a certified reference material (molecular formula C18H12ClNO2S, MW 341.81 g/mol) for analytical method development and quality control.
The molecular framework of N-(2-benzoyl-4-chlorophenyl)thiophene-2-carboxamide (C18H12ClNO2S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H12ClNO2S |
| Molecular Weight | 341.81 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
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Recommended Standards
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- 3-(Aminomethyl)cyclohexanol (CAS 116650-26-1)
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- 6-Bromo-7-chloro-8-methyl-4-oxo-1H-quinoline-2-carboxylic acid (CAS 1820674-78-9)
- 5-bromo-2-tert-butylpyridin-3-amine (CAS 2357504-70-0)
- 1-[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-[2-[(3-hydroxypropyl)amino]-5,6-dimethyl-1H-benzimidazol-1-yl]-ethanone (CAS 758679-97-9)
- Methyl 5-(3-carbamoylphenyl)pyridine-2-carboxylate (CAS 1820614-23-0)
- 2-Amino-4-iodobenzyl amine (CAS 1260885-34-4)
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