5-(Trifluoromethyl)benzo[b]thiophene-2-carboxylic acid CAS 244126-64-5
| CAS No. | 244126-64-5 |
| Molecular Formula | C10H5F3O2S |
| Molecular Weight | 246.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5-(Trifluoromethyl)benzo[b]thiophene-2-carboxylic acid (C10H5F3O2S) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
5-(Trifluoromethyl)benzo[b]thiophene-2-carboxylic acid (CAS 244126-64-5) is a high-purity analytical reference standard with the molecular formula C10H5F3O2S and a molecular weight of 246.21 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-(Trifluoromethyl)benzo[b]thiophene-2-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H5F3O2S |
| Molecular Weight | 246.21 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Related Trifluoromethyl Standards
- 5-[3-(Trifluoromethyl)phenyl]-1,3,4-oxadiazole-2(3H)-thione (CAS 108413-50-9)
- 6-Trifluoromethyl-benzo[b]thiophene-2-carboxylic acid (CAS 142329-22-4)
- 5-((Trifluoromethyl)thio)-1H-benzo[d]imidazole-2-carbaldehyde (CAS 1805694-84-1)
- 3-(Trifluoromethyl)benzo[b]thiophene-2-carboxylic acid (CAS 826995-51-1)
- 4-(Trifluoromethyl)-1-benzothiophene-2-carboxylic acid (CAS 826995-55-5)
- 5-(4-(Trifluoromethyl)phenyl)-1,3,4-oxadiazole-2-thiol (CAS 389120-03-0)
- 5-[3-(Trifluoromethyl)phenoxy]-1,2,3-thiadiazole (CAS 338421-08-2)
- 7-(Trifluoromethyl)benzo[b]thiophene-2-carboxylic acid (CAS 550998-66-8)
Recommended Standards
- 4,4’-Difluorobenzil (CAS 579-39-5)
- 5-Fluoro-1-(2-fluorophenyl)-1H-indazol-3(2H)-one (CAS 888952-52-1)
- 6-(Thiophen-2-yl)-4-(trifluoromethyl)pyridazin-3(2h)-one (CAS 866474-41-1)
- 4-(Thiazol-2-yl)-6-(trifluoromethyl)pyrimidin-2-amine (CAS 883004-32-8)
- Calcimycin hemimagnesium (CAS 72124-77-7)
- 5-(2-Bromophenyl)-4-ethyl-4h-1,2,4-triazole-3-thiol (CAS 328090-43-3)
- N-(2,4-Dimethoxyphenyl)-4-fluorobenzamide (CAS 331240-20-1)
- (2,2-Difluoroethyl)(1-phenylethyl)amine (CAS 1183296-08-3)
- N-(4-aminocyclohexyl)piperidine-4-carboxamide (CAS 1249169-56-9)
- 1,4-Diethynyl-2,5-bis(butyloxy)benzene (CAS 128834-29-7)
- 4-(Pyridin-4-yl)pyrrolidin-2-one (CAS 1268132-89-3)
- 3-(Tert-pentyloxy)piperidine (CAS 1248141-40-3)
- (7-Bromoquinolin-8-yl)methanol (CAS 1823338-46-0)
- D-Phe6-Tirzepatide (CAS CATO-CPTD788925)
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