2-Ethoxy-4-(trifluoromethoxy)phenol CAS 2451902-66-0
| CAS No. | 2451902-66-0 |
| Molecular Formula | C9H9F3O3 |
| Molecular Weight | 222.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Ethoxy-4-(trifluoromethoxy)phenol.
2-Ethoxy-4-(trifluoromethoxy)phenol (CAS 2451902-66-0), molecular formula C9H9F3O3 and molecular weight 222.16 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, 2-Ethoxy-4-(trifluoromethoxy)phenol is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 222.16 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2-Ethoxy-4-(trifluoromethoxy)phenol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H9F3O3 |
| Molecular Weight | 222.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | F-containing |
Related Ethoxy Standards
- 3-Ethoxy-5-(trifluoromethoxy)phenol (CAS 1881321-15-8)
- (2E)-3-(4-Ethoxy-2-methoxyphenyl)acrylic acid (CAS 1119452-97-9)
- 3-(2-Ethoxy-4-methoxyphenyl)acrylic acid (CAS 1372859-34-1)
- (2E)-3-(4-Ethoxy-3-methoxyphenyl)acrylic acid (CAS 144878-40-0)
- 2-Ethoxy-4-formylphenyl propanoate (CAS 159661-85-5)
- (2e)-3-(3-Ethoxy-4-methoxyphenyl)prop-2-enoic acid (CAS 161179-30-2)
- (2E)-3-(3-ethoxy-4-methoxyphenyl)acrylic acid (CAS 854883-46-8)
- (e)-3-(3-Ethoxy-2-methoxyphenyl)acrylic acid (CAS 855163-64-3)
Recommended Standards
- 2-[5-Ethyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetic acid (CAS 922516-30-1)
- 2-Isopropoxy-6-(trifluoromethyl)pyrimidin-4(3H)-one (CAS 37836-80-9)
- 2-(Propan-2-yl)-4-(trifluoromethyl)furan-3-carboxylic acid (CAS 2091455-01-3)
- 2-Methoxy-5-(2,2,2-trifluoro-1-hydroxyethyl)phenol (CAS 352339-76-5)
- Ethyl 2,4-dibromonicotinate (CAS 1034132-22-3)
- N-butyl-5-chloro-1H-pyrazolo[4,3-d]pyrimidin-7-amine (CAS 2750883-29-3)
- Cyclopropyl(3-fluorophenyl)methanamine hydrochloride (CAS 844470-94-6)
- 6-Chloro-2-fluoro-3-iodobenzoic acid (CAS 2056110-36-0)
- 6-Chloro-3-ethoxy-2-iodopyridine (CAS 1881463-83-7)
- [1,1'-Biphenyl]-4-yl 3-(furan-2-yl)acrylate (CAS 853349-58-3)
- 7-Chloro-3-methoxyquinolin-4-ol (CAS 855871-35-1)
- 3-(Aziridin-1-yl)-1-phenylpyrrolidine-2,5-dione (CAS 52380-78-6)
- 4-Oxo-1-(o-tolyl)cyclohexanecarboxylic acid (CAS 1385694-73-4)
- D-Ala35-Tirzepatide (CAS CATO-CPTD788904)
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