2,2,4-Trifluorobenzo[d][1,3]dioxole-5-carboxylic acid CAS 2451905-77-2
| CAS No. | 2451905-77-2 |
| Molecular Formula | C8H3F3O4 |
| Molecular Weight | 220.10 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, 2,2,4-Trifluorobenzo[d][1,3]dioxole-5-carboxylic acid is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 220.10 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
2,2,4-Trifluorobenzo[d][1,3]dioxole-5-carboxylic acid (CAS 2451905-77-2) is a high-purity analytical reference standard with the molecular formula C8H3F3O4 and a molecular weight of 220.10 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H3F3O4 |
| Molecular Weight | 220.10 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | F-containing |
Related Trifluorobenzo Standards
Recommended Standards
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- 2,7-Di-tert-butyl-9h-fluorene-9-carboxylic acid (CAS 351003-13-9)
- 1-(4-(Difluoromethoxy)phenyl)ethan-1-amine (CAS 136123-72-3)
- 2-Bromo-N-(1-phenylethyl)propanamide (CAS 25027-38-7)
- (2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-5-oxo-5-prop-2-enoxypentanoic acid (CAS 259221-91-5)
- 3-[(3,5-difluorophenyl)methyl]piperidine (CAS 1225687-78-4)
- Tau Peptide (275-305) (Repeat 2 Domain) trifluoroacetate salt (CAS 330456-25-2)
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