5,5'-(Thiophene-2,5-diyl)diisophthalaldehyde CAS 2459652-61-8
| CAS No. | 2459652-61-8 |
| Molecular Formula | C20H12O4S |
| Molecular Weight | 348.37 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5,5'-(Thiophene-2,5-diyl)diisophthalaldehyde (CAS 2459652-61-8), molecular formula C20H12O4S and molecular weight 348.37 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 5,5'-(Thiophene-2,5-diyl)diisophthalaldehyde (C20H12O4S) is characterized by a flavonoid core, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H12O4S |
| Molecular Weight | 348.37 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Sulfur Atoms | 1 |
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Recommended Standards
- 4-Oxo-2-phenyl-4H-chromen-3-yl thiophene-2-carboxylate (CAS 786663-61-4)
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- 4-Cyano-5-ethyl-3-(2-fluoro-[1,1-biphenyl]-4-yl)-1-methyl-1H-pyrrole-2-carboxylic acid (CAS 851196-32-2)
- Ethyl 4,5-dimethyl-2-(4-nitrobenzamido)thiophene-3-carboxylate (CAS 313507-39-0)
- 1-(2,2,2-Trifluoroethyl)naphthalene (CAS 123228-02-4)
- N-(4-Amino-2-chlorophenyl)-4-methoxybenzamide (CAS 861433-87-6)
- (3,5-Dimethyl-4-nitrophenyl)methanol (CAS 18515-22-5)
- 5-(4-(1H-Imidazol-1-yl)phenyl)-1-phenyl-1H-pyrazole (CAS 321385-61-9)
- 4-Chloro-5-methoxy-2H-indazole (CAS 1352395-04-0)
- N-(2,6-DIMETHOXYPHENYL)ACETAMIDE (CAS 131157-26-1)
- 1001499-93-9 2-Chloromethyl-2H-pyrazole-3-carboxylic acid methyl ester 2-chloromethyl-2 h-pyrazole-3-carboxylic acid methyl ester (CAS 1001499-93-9)
- Pitavastatin Impurity 18 (CAS CATO-C4X-103718)
- Rapamycin Impurity 29 (CAS CATO-C4X-174629)
- Semaglutide impurity 266 (CAS CATO-C4X-2226266)
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