3-(Trifluoromethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-amine CAS 24848-34-8
| CAS No. | 24848-34-8 |
| Molecular Formula | C4H2F3N5S |
| Molecular Weight | 209.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
3-(Trifluoromethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-amine (CAS 24848-34-8), molecular formula C4H2F3N5S and molecular weight 209.15 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 3-(Trifluoromethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-amine (C4H2F3N5S) is characterized by a nitrile group, sulfur-containing functionality, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), 3-(Trifluoromethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-amine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C4H2F3N5S |
| Molecular Weight | 209.15 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Related Trifluoromethyl Standards
- 6-(trifluoromethyl)furo[2,3-b]pyridin-3-one (CAS 1196155-86-8)
- 3-(Trifluoromethyl)-3,3a,4,5,6,7-hexahydrobenzo[c]isoxazol-3-ol (CAS 159152-82-6)
- 4-(trifluoromethyl)-3H-1,3-benzoxazol-2-one (CAS 1803829-31-3)
- 7-(trifluoromethyl)-3H-1,3-benzoxazol-2-one (CAS 1804033-60-0)
- 6-(trifluoromethyl)-3H-1,3-benzoxazol-2-one (CAS 1806520-96-6)
- 2-(trifluoromethyl)-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one (CAS 2306276-50-4)
- 1-Ethyl-5-(trifluoromethyl)-1h-1,2,3-triazole-4-carboxylic acid (CAS 1267110-06-4)
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Recommended Standards
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- (3-Cyclohexyl-1,2,4-oxadiazol-5-yl)methanamine (CAS 1039837-72-3)
- 4-(2-(4-Methylpiperazin-1-yl)thiazol-4-yl)benzene-1,2-diol (CAS 875471-69-5)
- 4-Cyano-2-hydroxybenzyl amine (CAS 741670-77-9)
- 4-[2-(Benzyloxy)ethoxy]benzoic acid (CAS 223268-58-4)
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- 3-(Aminomethyl)-3-(p-tolyl)cyclobutan-1-ol (CAS 1486451-88-0)
- 1-(2-Methoxythiazol-5-yl)-N-methylmethanamine (CAS 937688-48-7)
- 5-Chlorofuran-2-methanol (CAS 27230-59-7)
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- Insulin Degludec impurity 4 (CAS CATO-C4X-21574)
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