6-Bromo-8-fluoro-3,4-dihydro-1H-spiro[naphthalene-2,2'-[1,3]dioxolane] CAS 2489407-87-4
| CAS No. | 2489407-87-4 |
| Molecular Formula | C12H12BrFO2 |
| Molecular Weight | 287.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 287.12 g/mol gives 6-Bromo-8-fluoro-3,4-dihydro-1H-spiro[naphthalene-2,2'-[1,3]dioxolane] distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
6-Bromo-8-fluoro-3,4-dihydro-1H-spiro[naphthalene-2,2'-[1,3]dioxolane] (CAS 2489407-87-4), molecular formula C12H12BrFO2 and molecular weight 287.12 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 6-Bromo-8-fluoro-3,4-dihydro-1H-spiro[naphthalene-2,2'-[1,3]dioxolane] (C12H12BrFO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H12BrFO2 |
| Molecular Weight | 287.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | F/Br-containing |
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- 2,2-DICHLORO-N-(1,3-DIHYDROXY-1-(4-NITROPHENYL)PROPAN-2-YL)ACETAMIDE (CAS 579-51-1)
- 2-(3-Methylpiperidin-1-yl)-N-(naphthalen-1-yl)acetamide (CAS 653584-73-7)
- ((4R)-4-Fluoro-1,2-dimethylpyrrolidin-2-yl)methanol (CAS 2417920-93-3)
- Calcipotriol Impurity 12 (CAS 129831-99-8)
- 1-Oxa-6-azaspiro[3.4]octane hemioxalate (CAS 1523618-30-5)
- 3-(3,4-Dimethoxyphenyl)-1-(4-fluorobenzyl)-1H-pyrazole-4-carbaldehyde (CAS 1006479-97-5)
- 3-Amino-N-(5-methyl-1,2-oxazol-3-yl)benzene-1-sulfonamide (CAS 954563-97-4)
- 2-Pentylbenzo[d]isothiazol-3(2H)-one (CAS 4299-08-5)
- [14-31]-Semaglutide (CAS CATO-C4X-2226262)
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