2-Amino-5-(3-((4-(2-(chloromethyl)-1,3-dioxolan-2-yl)phenyl)amino)propyl)-6-methylpyrimidin-4(3H)-one CAS 2499-52-7
| CAS No. | 2499-52-7 |
| Molecular Formula | C18H23ClN4O3 |
| Molecular Weight | 378.85 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Amino-5-(3-((4-(2-(chloromethyl)-1,3-dioxolan-2-yl)phenyl)amino)propyl)-6-methylpyrimidin-4(3H)-one.
2-Amino-5-(3-((4-(2-(chloromethyl)-1,3-dioxolan-2-yl)phenyl)amino)propyl)-6-methylpyrimidin-4(3H)-one (CAS 2499-52-7) is a high-purity analytical reference standard with the molecular formula C18H23ClN4O3 and a molecular weight of 378.85 g/mol.
The molecular framework of 2-Amino-5-(3-((4-(2-(chloromethyl)-1,3-dioxolan-2-yl)phenyl)amino)propyl)-6-methylpyrimidin-4(3H)-one (C18H23ClN4O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Amino-5-(3-((4-(2-(chloromethyl)-1,3-dioxolan-2-yl)phenyl)amino)propyl)-6-methylpyrimidin-4(3H)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H23ClN4O3 |
| Molecular Weight | 378.85 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Amino Standards
- N-[6-Amino-1,2,3,4-tetrahydro-2,4-dioxo-1-(phenylmethyl)-5-pyrimidinyl]-2-chloro-N-(3-methylbutyl)acetamide (CAS 571917-23-2)
- (4-Amino-3-(((4-chlorophenyl)sulfonyl)methyl)phenyl)(pyrrolidin-1-yl)methanone (CAS 339101-80-3)
- 3-Amino-2-chloro-N-(furan-2-ylmethyl)-4-phenoxybenzenesulfonamide (CAS 88345-35-1)
- Ethyl 3-((2-amino-5-chlorophenyl)sulfonyl)-1H-indole-2-carboxylate (CAS 206256-17-9)
- 1-Amino-8-chloro-2-((4-methoxyphenyl)amino)anthracene-9,10-dione (CAS 88653-25-2)
- Methyl 2-((4-amino-5-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)pyrimidin-2-yl)thio)acetate (CAS 1823184-37-7)
- 861363-66-8 A841569 amino-[chloro-(3-nitrophenyl)methylidene]-(2,4,6-trichlorophenyl)ammonium azanyl-[chloranyl-(3-nitrophenyl)methylidene]-[2,4,6-tris(chloranyl)phenyl]azanium (CAS 861363-66-8)
- (R)-3-amino-1-(5-bromopyridin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoropropan-2-ol (CAS 1809323-29-2)
Recommended Standards
- 11-(4-Chlorophenyl)-8-methyl-2,3,4,5-tetrahydrocyclohepta[c]furo[3,2-g]chromen-6(1H)-one (CAS 858746-64-2)
- 2-Chloro-1-[5-(4-methoxyphenyl)-3-(naphthalen-2-yl)-4,5-dihydro-1h-pyrazol-1-yl]ethan-1-one (CAS 380196-82-7)
- 1-(2-Chlorobenzyl)-2-(3,4-dimethoxyphenyl)-1h-benzo[d]imidazole (CAS 431976-91-9)
- 6-Chloro-2-(4-methoxyphenyl)-1-[(4-methylphenyl)methoxy]-1H-1,3-benzodiazole (CAS 329234-97-1)
- N-(3,3-dimethyl-2-oxobutyl)formamide (CAS 1330754-91-0)
- N-(1-(2-Chlorobenzyl)pyrrolidin-3-yl)isoquinolin-5-amine (CAS 675132-98-6)
- 2-(Isoindolin-2-yl)aniline (CAS 95493-26-8)
- 2-(Aminomethyl)-3-(difluoromethyl)-5-fluoropyridine-6-acetonitrile (CAS 1805439-46-6)
- 5-Aminoindolin-2-one (CAS 20876-36-2)
- 11-Dehydroxygrevilloside B (CAS 197307-49-6)
- Ethyl 4,6-Dichloropyridazine-3-carboxylate (CAS 679406-03-2)
- 3-(4-Methoxy-3-(piperidin-1-ylsulfonyl)phenyl)propanoic acid (CAS 1707581-93-8)
- 5,5-Dimethoxypentanal (CAS 50789-30-5)
- Hippocampal Cholinergic Neurostimulating Peptide (CAS 140158-49-2)
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