4-[4-(4-Fluorophenyl)piperazino]aniline CAS 251097-69-5
| CAS No. | 251097-69-5 |
| Molecular Formula | C16H18FN3 |
| Molecular Weight | 271.33 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 4-[4-(4-Fluorophenyl)piperazino]aniline (C16H18FN3) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
4-[4-(4-Fluorophenyl)piperazino]aniline (CAS 251097-69-5), molecular formula C16H18FN3 and molecular weight 271.33 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H18FN3 |
| Molecular Weight | 271.33 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Fluorophenyl Standards
- N-(4-fluorophenyl)-1-(pyridin-4-yl)piperidin-4-amine (CAS 1094564-35-8)
- 1-(4-Fluorophenyl)-2,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indol-4-one (CAS 96757-76-5)
- 1-Benzyl-3-(4-fluorophenyl)pyrrolidin-3-ol (CAS 425663-33-8)
- 2-(4-(4-Fluorophenyl)piperazin-1-yl)aniline (CAS 603117-42-6)
- Methyl (3-((4-fluorophenyl)thio)propanoyl)glycinate (CAS 1156076-69-5)
- (3Z)-3-{[(4-fluorophenyl)amino]methylidene}-1,3-dihydro-2-benzothiophen-1-one (CAS 1164523-83-4)
- 4-(4-Fluorophenyl)-5-phenyl-4h-1,2,4-triazole-3-thiol (CAS 120873-34-9)
- 4-(2-Fluorophenyl)-6-(thiophen-2-yl)pyrimidin-2-amine (CAS 1263208-57-6)
Recommended Standards
- 4-(N-Butyl-N-methylsulfamoyl)benzoic acid (CAS 887202-44-0)
- 4-{[(3,4-dimethylphenyl)sulfonyl]amino}butanoic acid (CAS 857041-67-9)
- 4-(2,5-Dimethylbenzenesulfonamido)butanoic acid (CAS 743451-71-0)
- 4-Methyl-N-(pivaloyloxy)benzenesulfonamide (CAS 2088941-42-6)
- 2-[[(6-Chloro-3-pyridinyl)methyl]ethylamino]-2-(methylimino)acetic AcidDISCONTINUED (CAS 208764-24-3)
- Hydroxy Metronidazole (CAS 4812-40-2)
- 2-Chloro-3,3-dimethylbutyrophenone (CAS 898764-68-6)
- 1-(4-Fluorophenyl)-N3,N3-dimethylpropane-1,3-diamine (CAS 933700-53-9)
- 2-(2-(2-(4-(tert-Butyl)phenoxy)ethoxy)ethoxy)ethanol (CAS 89203-08-7)
- Dibenzo[a,j]acridin-3-ol (CAS 105467-66-1)
- (2,5-Dichlorophenyl)(4-(((4,5-dihydrothiazol-2-yl)thio)methyl)piperidin-1-yl)methanone (CAS 1396761-38-8)
- 4-Benzyl-2,2,6,6-Tetramethylmorpholine (CAS 58607-28-6)
- 4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}benzamide (CAS 339023-73-3)
- Semaglutide Impurity 145 (CAS CATO-C4X-2226145)
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