3-Chloro-2-{3-[(3-nitropyridin-2-yl)sulfanyl]-1H-1,2,4-triazol-1-yl}-5-(trifluoromethyl)pyridine CAS 251307-21-8
| CAS No. | 251307-21-8 |
| Molecular Formula | C13H6ClF3N6O2S |
| Molecular Weight | 402.74 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 3-Chloro-2-{3-[(3-nitropyridin-2-yl)sulfanyl]-1H-1,2,4-triazol-1-yl}-5-(trifluoromethyl)pyridine is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
3-Chloro-2-{3-[(3-nitropyridin-2-yl)sulfanyl]-1H-1,2,4-triazol-1-yl}-5-(trifluoromethyl)pyridine (CAS 251307-21-8) is a high-purity analytical reference standard with the molecular formula C13H6ClF3N6O2S and a molecular weight of 402.74 g/mol.
3-Chloro-2-{3-[(3-nitropyridin-2-yl)sulfanyl]-1H-1,2,4-triazol-1-yl}-5-(trifluoromethyl)pyridine (C13H6ClF3N6O2S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 3-Chloro-2-{3-[(3-nitropyridin-2-yl)sulfanyl]-1H-1,2,4-triazol-1-yl}-5-(trifluoromethyl)pyridine under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C13H6ClF3N6O2S |
| Molecular Weight | 402.74 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 6 |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 2-(3-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanyl}-1H-1,2,4-triazol-1-yl)-3-nitropyridine (CAS 251307-16-1)
- 3-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl}-1-(3-methoxypropyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile (CAS 338399-23-8)
- 3-Chloro-2-[4-(naphthalene-2-carbonyl)-1H-1,2,3-triazol-1-yl]-5-(trifluoromethyl)pyridine (CAS 478248-73-6)
- 4-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]propanoyl}-N-[(1E)-(methoxyimino)methyl]-1H-pyrrole-2-carboxamide (CAS 339099-79-5)
- 3-(2-(2-Chloro-4-nitrophenoxy)acetamido)-4-methylbenzene-1-sulfonyl fluoride (CAS 25299-96-1)
- 4-(2-(2-Chloro-4-nitrophenoxy)acetamido)-2-methylbenzene-1-sulfonyl fluoride (CAS 25292-73-3)
- 4-Chloro-N'-(3-(trifluoromethyl)quinoxalin-2-yl)benzenesulfonohydrazide (CAS 343372-46-3)
- 5-(2-Chloro-4-methanesulfonylphenyl)-1-[3-(trifluoromethyl)phenyl]-1H-1,2,3,4-tetrazole (CAS 400089-23-8)
Recommended Standards
- (-)-(S)-5,7-Bis[(tert-butyldimethylsilyl)oxy]-4,4-dimethylheptan-3-one (5S)-5,7-Bis-{[tert-butyldimethylsilyl)oxy]}-4,4-dimethylheptan-3-one 187527-25-9 (CAS 187527-25-9)
- 4-(4-Chlorophenyl)-1-((2,4-dichlorophenyl)sulfonyl)-1,2,3,6-tetrahydropyridine (CAS 866152-49-0)
- (2Z)-2-[(Z)-Benzoyl]-3-{1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazol-5-yl}prop-2-enenitrile (CAS 318248-56-5)
- 1,2-Bis(1-(trimethylsilyl)-1H-inden-3-yl)ethane (CAS 302912-04-5)
- 5,5',5''-Trimethyl-[1,1':3',1''-terphenyl]-2,2',2''-triol (CAS 71128-89-7)
- Methyl 3-(4-methoxyphenyl)-5-(trifluoromethyl)benzoate (CAS 1820608-86-3)
- 4-Amino-2-cyclopropoxybenzenesulfonamide (CAS 1243458-68-5)
- 3-((3,4-Dichlorobenzyl)sulfinyl)-4-phenyl-5-((3-(trifluoromethyl)phenoxy)methyl)-4H-1,2,4-triazole (CAS 956165-79-0)
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- 5H-Pyrazolo[3,4-d]pyrimidine-4,5-diamine (CAS 81375-82-8)
- (R)-1-(3-fluoro-5-methoxyphenyl)but-3-en-1-amine (CAS 1269783-95-0)
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- (Des-His1,Glu?)-Glucagon (1-29) amide (human, rat, porcine) (CAS 110084-95-2)
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