Pregabalin Impurity 126 CAS 2514962-85-5
| CAS No. | 2514962-85-5 |
| Molecular Formula | C13H22N2O2 |
| Molecular Weight | 238.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Pregabalin Impurity 126.
As a process- or degradation-related impurity, Pregabalin Impurity 126 (CAS 2514962-85-5, C13H22N2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Pregabalin Impurity 126 (C13H22N2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 238.33 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H22N2O2 |
| Molecular Weight | 238.33 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Nitrogen Atoms | 2 |
Related Pregabalin Standards
- Pregabalin Impurity 31 (CAS 185815-56-9)
- Pregabalin Impurity 19 (CAS 104700-36-9)
- Pregabalin Impurity 96 (CAS 51615-30-6)
- Pregabalin Impurity 57 (CAS CATO-C4X-131257)
- Pregabalin Impurity 55 (CAS CATO-C4X-131255)
- Pregabalin Impurity 56 (CAS CATO-C4X-131256)
- Pregabalin Impurity 97 (CAS 186038-82-4)
- Pregabalin Impurity 145 (CAS CATO-C4X-1312145)
Recommended Standards
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- Thiamine Impurity 15 (CAS 24941-82-0)
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- Oseltamivir Impurity 81 (CAS CATO-C4X-172081)
- Marmin (CAS 14957-38-1)
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- Pyridine, 3-bromo-6-chloro-2-hydrazinyl-, hydrochloride (1:1) (CAS 1956324-32-5)
- 2-Phenoxy-5-(1-tosylpiperidin-2-yl)pyridine (CAS 1352531-55-5)
- 4-Amino-1-butyl-5,6-dihydropyrimidin-2(1h)-one (CAS 877-54-3)
- 3-Ethylphenanthrene (CAS 1576-68-7)
- C-Peptide (human) (CAS 33017-11-7)
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