3-[2-(4-chloroquinazolin-8-yl)ethynyl]-1H-pyridin-2-one CAS 2516533-94-9
| CAS No. | 2516533-94-9 |
| Molecular Formula | C15H8ClN3O |
| Molecular Weight | 281.70 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 3-[2-(4-chloroquinazolin-8-yl)ethynyl]-1H-pyridin-2-one is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
3-[2-(4-chloroquinazolin-8-yl)ethynyl]-1H-pyridin-2-one (CAS 2516533-94-9) is a high-purity analytical reference standard with the molecular formula C15H8ClN3O and a molecular weight of 281.70 g/mol.
3-[2-(4-chloroquinazolin-8-yl)ethynyl]-1H-pyridin-2-one (C15H8ClN3O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 3-[2-(4-chloroquinazolin-8-yl)ethynyl]-1H-pyridin-2-one under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C15H8ClN3O |
| Molecular Weight | 281.70 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related chloroquinazolin Standards
- 3-[2-(4-chloroquinazolin-6-yl)ethynyl]-1H-pyridin-2-one (CAS 2545916-62-7)
- 6-((7-Chloroquinazolin-4-yl)amino)hexan-1-ol (CAS 5427-36-1)
- 4-(4-Chloroquinazolin-2-yl)-N,N-dimethylaniline (CAS 79916-53-3)
- 4-((7-Chloroquinazolin-2-yl)amino)phenol (CAS CATO-C3D-262799)
- Ethyl 2-((4-chloroquinazolin-7-yl)oxy)acetate (CAS 1000577-87-6)
- 4-(2-Chloroquinazolin-4-yl)thiomorpholine (CAS 39213-10-0)
- 3-(2-Chloroquinazolin-4-yl)benzonitrile (CAS 1292317-90-8)
- 4-((7-Chloroquinazolin-4-yl)amino)butanoic acid (CAS 165954-02-9)
Recommended Standards
- 3-[2-(7-chloro-1,8-naphthyridin-3-yl)ethynyl]-1H-pyridin-2-one (CAS 2448447-47-8)
- 1-(2-Chloro-9H-purin-6-yl)piperidine-3-carboxylic acid (CAS 919719-34-9)
- 6-[2-(2-chloro-3-pyridyl)ethynyl]-1H-1,8-naphthyridin-2-one (CAS 2571435-45-3)
- 1-(2-Chloro-7H-purin-6-yl)piperidine-4-carboxylic acid (CAS 919736-51-9)
- 2-(2,6-Dimethylbenzoyl)pyridine (CAS 898780-51-3)
- Ethyl 2-(6-cyanoimidazo[1,2-a]pyridin-3-yl)acetate (CAS 1034309-63-1)
- 4-({[(3-chlorophenyl)methyl]amino}methylidene)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-one (CAS 338975-70-5)
- (2S, 4S, 8S)-α-Tocopherol (CAS 77171-97-2)
- 6,7-Dihydro-5H-pyrrolo[1,2-c]imidazole-7-carboxylic acid (CAS 1369379-64-5)
- 1-Bromo-3-chloro-5-nitro-2-(trifluoromethyl)benzene (CAS 2169178-32-7)
- methyl 2-(4-aminophenyl)-2-methylpropanoate (CAS 54815-23-5)
- Papaverine Impurity 45 (CAS CATO-C4X-206745)
- Dimethoxydioctylsilane (CAS 947155-81-9)
- Tirzepatide Impurity 24 X TFA Salt (CAS CATO-C4X-324024)
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