2-(3,4-Dichlorophenoxy)-6-phenylnicotinonitrile CAS 252058-98-3
| CAS No. | 252058-98-3 |
| Molecular Formula | C18H10Cl2N2O |
| Molecular Weight | 341.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(3,4-Dichlorophenoxy)-6-phenylnicotinonitrile (CAS 252058-98-3), molecular formula C18H10Cl2N2O and molecular weight 341.19 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-(3,4-Dichlorophenoxy)-6-phenylnicotinonitrile (C18H10Cl2N2O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H10Cl2N2O |
| Molecular Weight | 341.19 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Dichlorophenoxy Standards
- 2-(3,4-Dichlorophenoxy)-5-phenylnicotinonitrile (CAS 338964-12-8)
- 3-((2,3-Dichlorophenoxy)methyl)-4-methoxybenzohydrazide (CAS 438218-58-7)
- (5-(2,4-Dichlorophenoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methanol (CAS 1006491-86-6)
- Methyl 4-(2,4-dichlorophenoxy)-3-nitrobenzoate (CAS 478246-38-7)
- N-[2-(2,4-Dichlorophenoxy)propyl]-3-ethoxyaniline (CAS 1040685-09-3)
- 2-(2,4-Dichlorophenoxy)-N-(4-methoxyphenyl)propanamide (CAS 284488-00-2)
- 4-(2,4-Dichlorophenoxy)-N-(4-fluorophenyl)butanamide (CAS 303091-85-2)
- 2-(2,4-Dichlorophenoxy)-N'-(3-oxocyclohex-1-en-1-yl)propanehydrazide (CAS 1024134-18-6)
Recommended Standards
- 2-(3,4-Dichlorophenyl)-7-(pyridin-2-yl)pyrazolo[1,5-a]pyrimidine (CAS 860610-16-8)
- 2-(2-Chlorophenoxy)-6-(4-chlorophenyl)pyridine-3-carbonitrile (CAS 252059-09-9)
- 2-cyano-N-({[(2,6-dichlorobenzyl)oxy]amino}methylene)-3-(dimethylamino)acrylamide (CAS 337919-76-3)
- 2-(2-Chlorophenoxy)-6-(2-chlorophenyl)pyridine-3-carbonitrile (CAS 306977-95-7)
- (3-Amino-4,6-dimethylthieno[2,3-b]pyridin-2-yl)(2-ethylpiperidin-1-yl)methanone (CAS 692747-81-2)
- 1-(2-Bromo-4-fluorophenyl)cyclopentanecarboxylic Acid (CAS 1898402-74-8)
- Dimethyl Pyridine-2,5-Dicarboxylate (CAS 881-86-7)
- 2-(2-Bromo-6-(chloromethyl)-3-(difluoromethyl)pyridin-4-yl)acetonitrile (CAS 1805369-34-9)
- 3-Amino-5-fluoro-2-methylbenzamide (CAS 1378802-64-2)
- 2-Chloro-4-methylbenzohydrazide (CAS 872495-45-9)
- (2R,3R,4S,5S,6R)-2-((6-chloro-1H-indol-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (CAS 467214-46-6)
- 3-(5-Chloro-1H-benzoimidazol-2-yl)-propionic acid (CAS 82138-56-5)
- 1-(7-Chloro-1-(2-methoxyethyl)-1H-benzo[d]imidazol-2-yl)ethan-1-one (CAS 1437435-21-6)
- 302798-54-5 (Leu31,Pro34)-Neuropeptide Y (13-36) (human, rat) MFCD00672463 (CAS 302798-54-5)
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