2-chloro-6-methylbenzene-1-sulfonyl chloride CAS 25300-37-2
| CAS No. | 25300-37-2 |
| Molecular Formula | C7H12Cl2O2S |
| Molecular Weight | 231.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-chloro-6-methylbenzene-1-sulfonyl chloride (CAS 25300-37-2) is a high-purity analytical reference standard with the molecular formula C7H12Cl2O2S and a molecular weight of 231.14 g/mol.
The molecular framework of 2-chloro-6-methylbenzene-1-sulfonyl chloride (C7H12Cl2O2S) is characterized by a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-chloro-6-methylbenzene-1-sulfonyl chloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H12Cl2O2S |
| Molecular Weight | 231.14 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | Cl-containing |
| Sulfur Atoms | 1 |
Related chloro Standards
- 2-chloro-4-methylbenzene-1-sulfonyl chloride (CAS 55311-94-9)
- 4-chloro-2-methyl-benzenesulfonyl chloride (CAS 56157-92-7)
- 5-Chloro-7-(chloromethyl)-2,2-dimethyl-2,3-dihydrobenzofuran (CAS 1234844-89-3)
- 5-Chloro-7-(chloromethyl)-3,3-dimethyl-2,3-dihydrobenzofuran (CAS 1234847-20-1)
- 5-Chloro-4-methylthiophene-2-sulfonyl Chloride (CAS 1353435-17-2)
- 4-Chloro-2-(1-chloroethyl)-6-cyclobutylpyrimidine (CAS 1427023-92-4)
- 3-Chloro-4-methylthiophene-2-sulfonyl chloride (CAS 2229137-51-1)
- 4-Chloro-3-methylthiophene-2-sulfonyl chloride (CAS 2855942-84-4)
Recommended Standards
- 2-(5-Fluoro-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-1-carboxamido)acetic acid (CAS 70767-70-3)
- Methyl (4-nitrophenyl) methylphosphonate (CAS 7284-49-3)
- ((4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl)phosphonic acid hydrate (CAS 25728-73-8)
- Pyridoxine Impurity 20 (CAS 36944-85-1)
- N-(Piperidin-3-yl)thiophene-2-sulfonamide hydrochloride (CAS 1261236-09-2)
- 2,4-Diamino-5-(4-fluorobenzyl)pyrimidine (CAS 836-06-6)
- n-(5-Chloro-2-methoxyphenyl)methanesulfonamide (CAS 519172-27-1)
- 2,6-Dimethyl-3-(4-fluorophenyl)propiophenone (CAS 898768-34-8)
- 4-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)phenoxy]-2-trifluoromethylbenzonitrile (CAS 1367127-44-3)
- 1h-1,3-Benzodiazol-7-amine dihydrochloride (CAS 37724-28-0)
- 4-Bromo-3-(difluoromethyl)-5-methoxy-2-methylpyridine (CAS 1805246-59-6)
- 6,8-Dichloro-3-(2-fluorobenzyl)quinazolin-4(3H)-one (CAS 302913-42-4)
- 2-((4-Chlorophenyl)amino)-6-(cyclohexylthio)quinazolin-4(1H)-one (CAS 828261-89-8)
- Neuroendocrine Regulatory Peptide-1 (rat) (CAS 954420-51-0)
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