2-Methoxy-N-(3-(trifluoromethyl)phenyl)benzamide CAS 25331-53-7
| CAS No. | 25331-53-7 |
| Molecular Formula | C15H12F3NO2 |
| Molecular Weight | 295.26 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2-Methoxy-N-(3-(trifluoromethyl)phenyl)benzamide (C15H12F3NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
2-Methoxy-N-(3-(trifluoromethyl)phenyl)benzamide (CAS 25331-53-7), molecular formula C15H12F3NO2 and molecular weight 295.26 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H12F3NO2 |
| Molecular Weight | 295.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Methoxy Standards
- 4-Methoxy-N-(4-(trifluoromethyl)phenyl)benzamide (CAS 150225-43-7)
- 2-Methoxy-N-(4-(trifluoromethyl)phenyl)benzamide (CAS 150225-47-1)
- 2-Methoxy-N-(2-(trifluoromethyl)phenyl)benzamide (CAS 314055-35-1)
- 4-Methoxy-N-(3-(trifluoromethyl)phenyl)benzamide (CAS 200630-42-8)
- 3-Methoxy-4-[2-(morpholin-4-yl)-2-oxoethoxy]benzoic acid (CAS 522624-59-5)
- 4-(8-Methoxy-4-oxo-3,4-dihydroquinazolin-2-yl)benzamide (CAS 220115-30-0)
- 4-Methoxy-N-(4-oxo-1,4-dihydroquinazolin-2-yl)benzamide (CAS 77478-79-6)
- Ethyl 5-(4-methoxy-3-nitrophenyl)-5-oxopentanoate (CAS 898758-91-3)
Recommended Standards
- 3-Hydroxy-4-methyl-n-[3-(trifluoromethyl)phenyl]benzamide (CAS 870221-73-1)
- 2,2-Difluoro-2-(4-fluorophenoxy)-N-(p-tolyl)acetamide (CAS 338792-40-8)
- 4-((4-(Trifluoromethyl)benzyl)amino)benzoic acid (CAS 64518-80-5)
- 2,2,2-Trifluoro-N-[(4-methylphenyl)methyl]-N-(pyrazin-2-yl)acetamide (CAS 866042-28-6)
- Dapoxetine Impurity 77 (CAS 85608-26-0)
- Gliclazide Impurity 2 (Methyl Tosylcarbamate) (CAS 14437-03-7)
- 1-(4-Fluoro-2-methylphenyl)propan-1-ol (CAS 1270582-94-9)
- Ethyl 3,3-difluoro-2-hydroxypent-4-enoate (CAS 1365970-40-6)
- 2,3,6-Trichloro-7-fluoroquinoxaline (CAS 1217303-10-0)
- 6-Chloro-2,3-dimethylquinoxaline-5,8-diol (CAS 7697-96-3)
- 5-Fluoro-2-(m-tolyloxy)aniline (CAS 937596-33-3)
- O-(Phenylmethyl)-D-threonine (CAS 86062-17-1)
- (E)-4-morpholinobut-2-enoic acid;hydrochloride (CAS 1419865-05-6)
- Semaglutide impurity 83 (CAS CATO-C4X-222683)
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