8-(Trifluoromethoxy)quinolin-4(1H)-one CAS 254435-42-2
| CAS No. | 254435-42-2 |
| Molecular Formula | C10H6F3NO2 |
| Molecular Weight | 229.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 8-(Trifluoromethoxy)quinolin-4(1H)-one.
8-(Trifluoromethoxy)quinolin-4(1H)-one (CAS 254435-42-2), molecular formula C10H6F3NO2 and molecular weight 229.16 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C10H6F3NO2, 8-(Trifluoromethoxy)quinolin-4(1H)-one contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 229.16 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 8-(Trifluoromethoxy)quinolin-4(1H)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H6F3NO2 |
| Molecular Weight | 229.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Trifluoromethoxy Standards
- 6-(Trifluoromethoxy)quinolin-4(1H)-one (CAS 1071540-62-9)
- 7-(Trifluoromethoxy)isoquinolin-1(2H)-one (CAS 1184917-30-3)
- 5-(Trifluoromethoxy)-1H-indole-2-carbaldehyde (CAS 1219928-85-4)
- 122454-46-0 3-Oxo-3-[4-(trifluoromethoxy)phenyl]propionitrile 3-oxo-3-[4-(trifluoromethoxy)phenyl]propanenitrile 4-(Trifluoromethoxy)benzoyl acetonitrile 4-(Trifluoromethoxy)benzoylacetonitrile 97% (CAS 122454-46-0)
- 5-[4-(Trifluoromethoxy)phenyl]-1,3-oxazole (CAS 1227954-44-0)
- 7-(Trifluoromethoxy)quinolin-2(1H)-one (CAS 1239461-99-4)
- 8-(Trifluoromethoxy)quinolin-2(1H)-one (CAS 1261626-98-5)
- 5-(Trifluoromethoxy)quinolin-4-ol (CAS 1261749-07-8)
Recommended Standards
- 7-Amino-2-(difluoromethyl)-9-fluoro-4H-pyrido[1,2-a]pyrimidin-4-one (CAS 2275753-35-8)
- 8-(Trifluoromethoxy)quinolin-4-ol (CAS 40516-41-4)
- 7-(Trifluoromethyl)quinoline-2,4(1H,3H)-dione (CAS 2252407-92-2)
- Methyl 2-cyano-4-(trifluoromethyl)benzoate (CAS 61500-86-5)
- 2-[[5-(Aminomethyl)-2-pyridinyl](methyl)amino]-1-ethanol (CAS 1178939-85-9)
- N-(6-Acetylnaphthalen-2-yl)-2-nitrobenzenesulfonamide (CAS 1998216-43-5)
- 9-Chloro-1-methyl-5,6,7,8-tetrahydro-1h-pyrazolo[4,3-b]quinoline (CAS 938001-63-9)
- 2-Methyl-3-((tetrahydrofuran-2-yl)methyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (CAS 1708288-29-2)
- 31124-35-3 (1-~13~C)Ethenylbenzene DTXSID60746134 (CAS 31124-35-3)
- 2'-Methoxy-[1,1'-biphenyl]-2-amine hydrochloride (CAS 1172517-34-8)
- 2,4,6,8-Tetrachloroquinazoline (CAS 54185-42-1)
- 2-methyl-1-[3-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydro-1H-indol-4-amine hydrochloride (CAS 1221725-69-4)
- (4-((2,5-Dihydro-1H-pyrrol-1-yl)methyl)phenyl)(4-methoxyphenyl)methanone (CAS 898763-81-0)
- D-[Phe]6-Semaglutide (CAS CATO-CPTD788633)
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