2-Chloro-4-(trifluoromethyl)benzamide CAS 254880-52-9
| CAS No. | 254880-52-9 |
| Molecular Formula | C8H5ClF3NO |
| Molecular Weight | 223.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-Chloro-4-(trifluoromethyl)benzamide (CAS 254880-52-9) is a high-purity analytical reference standard with the molecular formula C8H5ClF3NO and a molecular weight of 223.58 g/mol.
The molecular framework of 2-Chloro-4-(trifluoromethyl)benzamide (C8H5ClF3NO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H5ClF3NO |
| Molecular Weight | 223.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 1-(6-Chloro-2-(trifluoromethyl)pyridin-3-yl)ethan-1-one (CAS 1060810-87-8)
- 1-(2-Chloro-6-(trifluoromethyl)pyridin-4-yl)ethanone (CAS 1060810-89-0)
- 3-Chloro-4-(trifluoromethyl)benzamide (CAS 1092460-78-0)
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- 1-(6-Chloro-5-(trifluoromethyl)pyridin-2-yl)ethanone (CAS 1245915-39-2)
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Recommended Standards
- 2-Chloro-3-(trifluoromethyl)benzamide (CAS 39959-94-9)
- 2-Chloro-6-(trifluoromethyl)benzamide (CAS 916420-45-6)
- 1-[2-chloro-6-(trifluoromethyl)pyridin-3-yl]ethan-1-one (CAS 944900-15-6)
- 2-Chloro-N-(2,3,4-trifluorophenyl)acetamide (CAS 243644-03-3)
- imidazo[1,2-a]pyrazin-6-amine (CAS 1159818-69-5)
- N,N-diallyl-N-[1-(aminomethyl)-2-methylpropyl]amine (CAS 1000931-94-1)
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