N,O-Bis(trimethylsilyl)trifluoroacetamide CAS 25561-30-2

Purity Technical GradeIn StockPharmaceutical Standards
CAS No.25561-30-2
Molecular FormulaC8H18F3NOSi2
Molecular Weight257.40 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

N,O-Bis(trimethylsilyl)trifluoroacetamide CAS 25561-30-2 chemical structure

Description

Compared with other compounds in its class, the molecular weight of 257.40 g/mol gives N,O-Bis(trimethylsilyl)trifluoroacetamide distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

N,O-Bis(trimethylsilyl)trifluoroacetamide (CAS 25561-30-2) is a high-purity analytical reference standard with the molecular formula C8H18F3NOSi2 and a molecular weight of 257.40 g/mol.

Structurally, N,O-Bis(trimethylsilyl)trifluoroacetamide (C8H18F3NOSi2) contains an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of -1.0, corresponding to approximately 0 ring(s) or double-bond equivalent(s). With a molecular weight of 257.40 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC8H18F3NOSi2
Molecular Weight257.40 g/mol
PurityTechnical Grade
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in methanol, acetonitrile, DMSO, water (slightly soluble)
StabilityLight-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)-1.0
CAS Registry Year (est.)1964
Halogen ContentF-containing
Nitrogen Atoms1

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