3-Methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)phenol CAS 2557358-38-8
| CAS No. | 2557358-38-8 |
| Molecular Formula | C14H18BF3O3 |
| Molecular Weight | 302.10 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 3-Methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)phenol (C14H18BF3O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
3-Methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)phenol (CAS 2557358-38-8), molecular formula C14H18BF3O3 and molecular weight 302.10 g/mol, is a CATO reference standard with documented purity and traceability.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures 3-Methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)phenol under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H18BF3O3 |
| Molecular Weight | 302.10 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2001 |
| Halogen Content | F-containing |
Related Methyl Standards
- 4,4,5,5-Tetramethyl-2-(3-methyl-5-(trifluoromethoxy)phenyl)-1,3,2-dioxaborolane (CAS 1150561-56-0)
- (5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)phenyl)methanol (CAS 1220219-33-9)
- 4,4,5,5-Tetramethyl-2-(2-methyl-4-(trifluoromethoxy)phenyl)-1,3,2-dioxaborolane (CAS 1309980-29-7)
- (4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)phenyl)methanol (CAS 2370026-77-8)
- (4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)phenyl)methanol (CAS 2377611-99-7)
- 4,4,5,5-Tetramethyl-2-(2-(2,2,2-trifluoroethoxy)phenyl)-1,3,2-dioxaborolane (CAS 864754-11-0)
- Methyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-2-carboxylate (CAS 1227664-19-8)
- Methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-6-carboxylate (CAS 1527007-77-7)
Recommended Standards
- 2-[3-(Difluoromethyl)-4-fluoro-2-methoxyphenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2649471-81-6)
- 4-(2,2,2-Trifluoroethoxy)phenylboronic Acid Pinacol Ester (CAS 886528-42-3)
- 2,2,2-Trifluoro-1-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanol (CAS 2304631-56-7)
- 4-(Trifluoromethoxy)benzylboronic Acid Pinacol Ester (CAS 872038-32-9)
- 5-(3-Nitrophenyl)-1,3,4-thiadiazol-2-amine (CAS 833-47-6)
- 4-(5-Ethyl-1,2,4-oxadiazol-3-yl)-2-methylphenol (CAS 475651-47-9)
- 3Bromo-7,8-dihydroquinolin-6(5H)-one (CAS 1196157-23-9)
- Azilsartan Impurity 139 (CAS CATO-C4X-1096139)
- Methyl 2,2-dibromo-1-methylcyclopropane-1-carboxylate (CAS 39647-01-3)
- 2-(chloromethyl)-1-fluoro-4-iodobenzene (CAS 1261749-34-1)
- 1-(2-Chlorophenyl)-3-(5-hydroxy-3-phenylpentyl)urea (CAS 1795301-96-0)
- Methyl 4-fluoro-1-naphthoate (CAS 13772-56-0)
- p-Chlorobenzene isocyanate (CAS 104-12-1)
- Tau Peptide (245-274) (Repeat 1 Domain) trifluoroacetate salt (CAS 1428134-39-7)
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