Methyl 5-(chlorocarbonyl)nicotinate CAS 25761-06-2
| CAS No. | 25761-06-2 |
| Molecular Formula | C8H6ClNO3 |
| Molecular Weight | 199.59 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Methyl 5-(chlorocarbonyl)nicotinate is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Methyl 5-(chlorocarbonyl)nicotinate (CAS 25761-06-2), molecular formula C8H6ClNO3 and molecular weight 199.59 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Methyl 5-(chlorocarbonyl)nicotinate (C8H6ClNO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures Methyl 5-(chlorocarbonyl)nicotinate under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H6ClNO3 |
| Molecular Weight | 199.59 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Methyl Standards
- Methyl 6-(chlorocarbonyl)nicotinate (CAS 169124-35-0)
- Methyl 2-(chlorocarbonyl)nicotinate (CAS 88234-87-1)
- 3-(Chlorocarbonyl)phenyl Acetate (CAS 16446-73-4)
- 2-(4-(Chlorocarbonyl)phenyl)acetic acid (CAS 81911-36-6)
- Methyl 2-(chlorocarbonyl)benzoate (CAS 4397-55-1)
- methyl 4-chlorocarbonyl-1-methyl-pyrrole-2-carboxylate (CAS 162226-85-9)
- Methyl 5-(chlorocarbonyl)-2-methyl-1H-pyrrole-3-carboxylate (CAS 40593-27-9)
- N-(Chlorocarbonyl)benzimidoyl chloride (CAS 4547-71-1)
Recommended Standards
- Methyl 4-chloro-5-formylnicotinate (CAS 2803902-45-4)
- methyl 6-(carbonochloridoyl)pyridine-2-carboxylate (CAS 94111-79-2)
- Methyl 6-chloro-2-formylnicotinate (CAS 97367-98-1)
- 6-Chloro-4-methoxyisoxazolo[5,4-b]pyridin-3-amine (CAS 2868296-12-0)
- 7-Bromo-3-chlorobenzo[d]isoxazole (CAS 1260677-07-3)
- (2S,4S)-4-(tert-Butoxy)-1-isopropylpyrrolidine-2-carboxylicacid (CAS 1263078-26-7)
- N-(Benzo[d][1,3]dioxol-5-yl)-2-((6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)thio)acetamide (CAS 460726-55-0)
- Ethyl 2-chloroimidazo[1,5-a]pyrimidine-8-carboxylate (CAS 1250998-26-5)
- Cytidine 5'-Monophosphate (CAS 63-37-6)
- 4-Fluoro-1H-pyrrolo[2,3-b]pyridine-6-carboxylic acid (CAS 1190322-19-0)
- 3-Chloro-5-fluoroisonicotinaldehyde (CAS 1227603-79-3)
- 2-Ethyl-3-methylquinolin-8-ol (CAS 88611-52-3)
- 3-Phenyl-1H-pyrazol-5-ol (CAS 5203-91-8)
- Palmitoyl Tripeptide-1 HCl (CAS 2757690-14-3)
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