SPiro[1,3-dioxolane-2,3′-[1,2,4]metheno[3H]cyclobuta[cd]pentalen]-5′(1′H)-one, 2′,5′a-dibromohexahydro- CAS 25867-84-9
| CAS No. | 25867-84-9 |
| Molecular Formula | C12H10Br2O3 |
| Molecular Weight | 362.01 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of SPiro[1,3-dioxolane-2,3′-[1,2,4]metheno[3H]cyclobuta[cd]pentalen]-5′(1′H)-one, 2′,5′a-dibromohexahydro- is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies SPiro[1,3-dioxolane-2,3′-[1,2,4]metheno[3H]cyclobuta[cd]pentalen]-5′(1′H)-one, 2′,5′a-dibromohexahydro- (CAS 25867-84-9), a certified reference material (molecular formula C12H10Br2O3, MW 362.01 g/mol) for analytical method development and quality control.
SPiro[1,3-dioxolane-2,3′-[1,2,4]metheno[3H]cyclobuta[cd]pentalen]-5′(1′H)-one, 2′,5′a-dibromohexahydro- (C12H10Br2O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H10Br2O3 |
| Molecular Weight | 362.01 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | Br-containing |
Related SPiro Standards
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- SPIRO[1,3-DIOXOLANE-2,9’-[9H]FLUORENE]-4,5-DICARBOXYLIC ACID DIETHYL ESTER (CAS 129178-60-5)
- Spiro[3H-2-benzopyran-3,5’(3’aH)-[1,3]dioxolo[4,5-g]isoquinoline], 1,4,7’,8’-tetrahydro-7,8-dimethoxy-6’-methyl- (CAS 87264-55-9)
- Spiro[fluorene-9,9'-xanthen]-2-ylboronic acid (CAS 1799644-51-1)
- Spiro[fluorene-9,9'-xanthen]-4-ylboronic acid (CAS 2244281-69-2)
- Spiro[4H-cyclohepta[2,1-a:3,4-a′]dinaphthalene-4,1′-[2,4]cyclopentadiene], 3,5-dihydro-, (S)- (CAS 125443-42-7)
- Spiro[fluorene-9,9'-xanthene]-2',7'-dicarbonitrile (CAS 152480-82-5)
- Spiro[benzo[c]fluorene-7,9'-xanthene] (CAS 1639407-50-3)
Recommended Standards
- Ethyl 6,8-dibromo-2H-chromene-3-carboxylate (CAS 885271-30-7)
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- 5-Iodo-1-isopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (CAS 2377612-00-3)
- Ethyl 6,8-dibromo-5-methylimidazo[1,2-a]pyridine-2-carboxylate (CAS 859787-43-2)
- Almotriptan EP Impurity E Hydrochloride (CAS 1391054-49-1)
- Methyl 4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxylate (CAS 1801143-19-0)
- 2-(2-(Neopentylamino)ethoxy)ethan-1-ol (CAS 1247232-37-6)
- 5-Chloro-2-methoxyphenethyl acetate (CAS 1443312-15-9)
- 3-(Boc-amino)-L-phenylalanine Methyl Ester (CAS 1213950-42-5)
- 6-Chloro-2-(isopentyloxy)nicotinic acid (CAS 1339335-83-9)
- 6-Fluoro-3-methylbenzo[b]thiophene-2-carbaldehyde (CAS 1398497-04-5)
- 4-(Bromoethynyl)-1,1'-biphenyl (CAS 1321929-32-1)
- 7,7-dimethyl-1,3-diazaspiro[4.4]nonane-2,4-dione (CAS 1536184-51-6)
- Tau Peptide (244-274) (Repeat 1 Domain) trifluoroacetate salt (CAS 330456-24-1)
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