1-[2,4-dichloro-6-(trifluoromethyl)phenyl]-1H-pyrrole-2-carboxaldehyde CAS 259251-85-9
| CAS No. | 259251-85-9 |
| Molecular Formula | C12H6Cl2F3NO |
| Molecular Weight | 308.08 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-[2,4-dichloro-6-(trifluoromethyl)phenyl]-1H-pyrrole-2-carboxaldehyde.
1-[2,4-dichloro-6-(trifluoromethyl)phenyl]-1H-pyrrole-2-carboxaldehyde (CAS 259251-85-9), molecular formula C12H6Cl2F3NO and molecular weight 308.08 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 1-[2,4-dichloro-6-(trifluoromethyl)phenyl]-1H-pyrrole-2-carboxaldehyde (C12H6Cl2F3NO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H6Cl2F3NO |
| Molecular Weight | 308.08 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related dichloro Standards
- 1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-pyrrole-2-carboxaldehyde (CAS 259175-25-2)
- 4,5-dichloro-6-methyl-2-[5-(trifluoromethyl)-2-pyridyl]pyrimidine (CAS 266679-65-6)
- 6,8-Dichloro-N-(pyridin-4-yl)imidazo-[1,2-b]pyridazine-3-carboxamide (CAS 1177415-93-8)
- 1-[2,4-dichloro-6-(trifluoromethyl)phenyl]-2,5-dimethyl-1H-pyrrole (CAS 259252-15-8)
- 1,3-Dichloro-7-hydroxy-9,9-dimethylacridin-2(9H)-one (CAS 118290-05-4)
- 3,5-Dichloro-3-(2-methoxyphenyl)indolin-2-one (CAS 169040-43-1)
- 5,7-Dichloro-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-c]pyridine (CAS 1951402-78-0)
- 3-(3,6-Dichloro-9h-carbazol-9-yl)propanoic acid (CAS 300816-42-6)
Recommended Standards
- [2-iodo-5-(trifluoromethyl)phenyl]methanol (CAS 702641-05-2)
- 4-(3,5-Dichlorophenyl)-2-(trifluoromethyl)pyridin-3-ol (CAS 1361880-20-7)
- N-(5-(2-Bromoacetyl)-6-(difluoromethyl)pyrazin-2-yl)acetamide (CAS 2920210-59-7)
- 2-Bromo-7-nitrodibenzo[b,e][1,4]dioxine (CAS 100125-06-2)
- Oxetan-2-ylmethyl 4-methylbenzene-1-sulfonate (CAS 115845-51-7)
- KDU691 (CAS 1513879-19-0)
- 2-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline (CAS 761440-75-9)
- 3-(Phenylethynyl)benzonitrile (CAS 37696-03-0)
- 2-Amino-7-(4-oxo-4-(pyridin-3-yl)butyl)-1H-purin-6(7H)-one (CAS 502507-75-7)
- 2-(1,2-Dimethyl-1H-imidazol-5-yl)-3,5-dimethylpyridine (CAS 771541-03-8)
- Isopropyl 2-amino-2-methylpropanoate (CAS 131322-68-4)
- 909858-38-4 3-(1-methyl-1H-pyrrol-2-yl)-1H-pyrazole-5-carboxylic acid DTXSID40349400 (CAS 909858-38-4)
- 4-Bromo-3-iodo-N,N-dimethylaniline (CAS 1291063-32-5)
- (2S)-2-amino-4-(hydroxymethylphosphinyl)butanoyl-L-alanyl-L-alanine (2S)-2-amino-4-[hydroxy(methyl)phosphinoyl]butyryl-L-alanyl-L-alanine 2-Amino-4-(methylphosphino)butyrylalanylalanine 35597-43-4 Antibiotic SF 1293 Bialaphos CHEBI:3088 L-phosphinothricyl-L-alanyl-L-alanine N-{(2S)-2-amino-4-[hydroxy(methyl)phosphoryl]butanoyl}-L-alanyl-L-alanine PTT Phosphinothricylalanylalanine bilanafos gamma-(Hydroxymethylphosphinyl)-L-alpha-aminobutyryl-L-alanyl-L-alanine phosphinothricin tripeptide (CAS 35597-43-4)
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