7-chloro-5-fluoro-1H-indole CAS 259860-01-0
| CAS No. | 259860-01-0 |
| Molecular Formula | C8H13ClFN |
| Molecular Weight | 177.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 7-chloro-5-fluoro-1H-indole.
CATO supplies 7-chloro-5-fluoro-1H-indole (CAS 259860-01-0), a certified reference material (molecular formula C8H13ClFN, MW 177.65 g/mol) for analytical method development and quality control.
Structurally, 7-chloro-5-fluoro-1H-indole (C8H13ClFN) contains a nitrile group, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 2.0, corresponding to approximately 2 ring(s) or double-bond equivalent(s). With a molecular weight of 177.65 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H13ClFN |
| Molecular Weight | 177.65 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related chloro Standards
- 2-Chloro-5-(ethoxymethyl)thiazole (CAS 1209494-04-1)
- 4-chloro-6-fluoro-1H-indole (CAS 885520-79-6)
- 5-Chloro-2-isopropylisothiazol-3(2H)-one (CAS 260370-55-6)
- 6-chloro-4-fluoro-1H-indole (CAS 885520-88-7)
- 6-chloro-7-fluoro-1H-indole (CAS 259860-04-3)
- 4-Chloro-5-(propylthio)-4H-1,2,3-triazole (CAS 664979-97-9)
- 7-chloro-[1,2,4]triazolo[4,3-c]pyrimidin-3-amine (CAS 1306605-83-3)
- 5-chloro-1H-pyrazolo[4,3-d]pyrimidin-3-amine (CAS 1550762-43-0)
Recommended Standards
- Clomethiazole Impurity 1 (CAS 72579-01-2)
- 3-(Chloromethyl)-n,n-dimethyl-1,2,4-thiadiazol-5-amine (CAS 32577-97-2)
- 5-(Chloromethyl)-2-ethoxythiazole (CAS 937655-31-7)
- 2-chloro-N-(pentan-2-yl)propanamide (CAS 1016808-29-9)
- 2-((tert-Butoxycarbonyl)amino)thieno[2,3-b]pyridine-3-carboxylic acid (CAS 1042441-74-6)
- 5-Chloro-2-(2-propyn-1-yloxy)benzenemethanol (CAS 400751-45-3)
- 2-((3-Fluorobenzyl)amino)butan-1-ol (CAS 1038259-55-0)
- 1-(3,4-Dichlorophenyl)prop-2-en-1-ol (CAS 103058-93-1)
- 6-(Tert-butyl)-2-(4-hydroxypiperidin-1-yl)pyrimidine-4-carboxylic acid (CAS 1355173-10-2)
- 6-Chloro-5-nitro-1H-indazole-3-carboxylic acid (CAS 1245645-05-9)
- Semaglutide Impurity 188 (CAS CATO-C4X-2226188)
- 5-(Methoxymethyl)-4-(1-naphthyl)-4H-1,2,4-triazole-3-thiol (CAS 337498-86-9)
- Vatred13 (CAS 4392-71-6)
- Osteogenic Growth Peptide (CAS 132996-61-3)
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