[3-(chloromethyl)phenyl]{4-[3-(trifluoromethyl)pyridin-2-yl]piperazino}methanone CAS 260367-78-0
| CAS No. | 260367-78-0 |
| Molecular Formula | C18H17ClF3N3O |
| Molecular Weight | 383.80 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of [3-(chloromethyl)phenyl]{4-[3-(trifluoromethyl)pyridin-2-yl]piperazino}methanone is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
[3-(chloromethyl)phenyl]{4-[3-(trifluoromethyl)pyridin-2-yl]piperazino}methanone (CAS 260367-78-0) is a high-purity analytical reference standard with the molecular formula C18H17ClF3N3O and a molecular weight of 383.80 g/mol.
The molecular framework of [3-(chloromethyl)phenyl]{4-[3-(trifluoromethyl)pyridin-2-yl]piperazino}methanone (C18H17ClF3N3O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures [3-(chloromethyl)phenyl]{4-[3-(trifluoromethyl)pyridin-2-yl]piperazino}methanone under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H17ClF3N3O |
| Molecular Weight | 383.80 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related chloromethyl Standards
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Recommended Standards
- 3-(3-Chlorobenzenesulfonyl)-1-ethyl-6,7-difluoro-1,4-dihydroquinolin-4-one (CAS 1326863-28-8)
- 1-(4-(4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)phenyl)ethan-1-one (CAS 338979-19-4)
- 2-chloro-N-[2-[(7-methyl-2,3-dihydro-1H-inden-4-yl)oxy]-5-(trifluoromethyl)phenyl]acetamide (CAS 303010-43-7)
- 1-{3-[4-(4-chlorophenyl)piperazin-1-yl]-5-(trifluoromethyl)pyridin-2-yl}ethan-1-one (CAS 900015-68-1)
- 3-Chloro-6-fluorobenzisoxazole (CAS 374554-89-9)
- Methyl 4-Acetamido-5-chloro-2-ethoxybenzoate (CAS 4235-43-2)
- Ethyl 5-nitro-nicotinate (CAS 1462-89-1)
- 3-(4-Cyanobenzoyl)-4-methylpyridine (CAS 1187167-48-1)
- Protokylol - API Standards (CAS 136-70-9)
- Ethyl 5-(2,4-dichlorophenyl)-3-(3-hydroxy-1-oxo-1H-inden-2-yl)-4,6-dioxo-1,3a,4,5,6,6a-hexahydropyrrolo[3,4-c]pyrrole-1-carboxylate (CAS 321522-11-6)
- Benzo[c][1,2,5]oxadiazol-5-ylboronic acid (CAS 426268-09-9)
- 2-(2-Isopropylthiazol-4-yl)ethan-1-amine hydrochloride (CAS 1269288-69-8)
- 2-[2-(Trifluoromethyl)phenyl]pyrrolidine (CAS 524674-04-2)
- Pancreatic Polypeptide (bovine) (CAS 179986-89-1)
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