(2E)-N-(4-Chlorophenyl)-3-[4-(trifluoromethoxy)phenyl]prop-2-enamide CAS 260555-67-7
| CAS No. | 260555-67-7 |
| Molecular Formula | C16H11ClF3NO2 |
| Molecular Weight | 341.71 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (2E)-N-(4-Chlorophenyl)-3-[4-(trifluoromethoxy)phenyl]prop-2-enamide.
(2E)-N-(4-Chlorophenyl)-3-[4-(trifluoromethoxy)phenyl]prop-2-enamide (CAS 260555-67-7), molecular formula C16H11ClF3NO2 and molecular weight 341.71 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, (2E)-N-(4-Chlorophenyl)-3-[4-(trifluoromethoxy)phenyl]prop-2-enamide is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 341.71 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H11ClF3NO2 |
| Molecular Weight | 341.71 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- 5-(2-Chloro-4-(trifluoromethyl)phenoxy)-3-ethylbenzo[d]isoxazole (CAS 114195-16-3)
- 3-(3-(2-Chlorophenyl)-1,2,4-oxadiazol-5-yl)-6-fluoroquinolin-4(1H)-one (CAS 1081119-02-9)
- 1-(2-Chloro-4-nitrophenyl)-3-(ethoxycarbonyl)-4,5-dihydro-1h-pyrazole-5-carboxylic acid (CAS 1264047-28-0)
- Diiodo(phenyl)borane (CAS 17381-60-1)
- 5-(4-Methylpiperazin-1-yl)picolinic acid (CAS 892501-96-1)
- Tert-butyl 7-methoxy-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-1'-carboxylate (CAS 2306261-79-8)
- 2-(Naphthalen-1-yl)propanenitrile (CAS 24168-42-1)
- 4,7-Methano-1H-inden-6-ol, 3a,4,5,6,7,7a-hexahydro-, polymer with 1,3-diisocyanatomethylbenzene (CAS 67969-76-0)
- 4-[Ethyl(methyl)amino]benzoic acid (CAS 861601-84-5)
- 3,3-Diphenylacrylaldehyde (CAS 13702-35-7)
- (4r)-2-(6-Methoxyquinolin-2-yl)thiazolidine-4-carboxylic acid (CAS 956918-99-3)
- 2,7-Dimethoxy-1,8-naphthyridine-4-carbaldehyde (CAS 1820648-98-3)
- Phenyl(1H-1,2,3-triazol-4-yl)methanol (CAS 1312782-59-4)
- Tetrapeptide-30/Tegopep (CAS 1036207-61-0)
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