ent-Cefradine EP Impurity B CAS 26108-29-2
| CAS No. | 26108-29-2 |
| Molecular Formula | C8H11NO2 |
| Molecular Weight | 153.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, ent-Cefradine EP Impurity B (CAS 26108-29-2, C8H11NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, ent-Cefradine EP Impurity B (C8H11NO2) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 153.18 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H11NO2 |
| Molecular Weight | 153.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Nitrogen Atoms | 1 |
Related ent Standards
- Cefradine EP Impurity B (CAS 26774-88-9)
- Cefradine lmpurity 21 (CAS 20763-30-8)
- Cefradine Impurity 25 (CAS CATO-C4X-121525)
- Cefradine Impurity 5 (CAS 1379292-16-6)
- Cefradine Impurity 28 (CAS 220275-58-1)
- Cefradine EP Impurity A/Cefadroxil EP Impurity B (CAS 22252-43-3)
- Cefradine Impurity 17 (CAS CATO-C4X-121517)
- Cefradine EP Impurity G(Cefalexin EP Impurity E/Cefadroxil EP Impurity H) (CAS 146794-70-9)
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