Diphenyl phosphoryl azide (DPPA) CAS 26386-88-9
| CAS No. | 26386-88-9 |
| Molecular Formula | C12H10N3O3P |
| Molecular Weight | 275.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Diphenyl phosphoryl azide (DPPA) (CAS 26386-88-9) is a high-purity analytical reference standard with the molecular formula C12H10N3O3P and a molecular weight of 275.20 g/mol.
The molecular framework of Diphenyl phosphoryl azide (DPPA) (C12H10N3O3P) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a phosphonate group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H10N3O3P |
| Molecular Weight | 275.20 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Nitrogen Atoms | 3 |
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- 3,9-Bis[2-(3,5-diamino-2,4,6-triazaphenyl)ethyl]-2,4,8,10-tetraoxaspiro[5.5]undecane (CAS 22535-90-6)
- 1-(2,6-Difluoropyridin-3-yl)-2,2,2-trifluoroethanone (CAS 1707361-89-4)
- 2-(1,1-Dioxidothiomorpholino)-3-(1H-indol-3-yl)-N-phenethylpropanamide (CAS 478040-67-4)
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- 2-(3-Chloro-1H-1,2,4-triazol-1-yl)acetamide (CAS 1630763-41-5)
- 3-(4-Ethoxyphenoxy)propanenitrile (CAS 1016803-66-9)
- Semaglutide impurity 271 (CAS CATO-C4X-2226271)
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