5-(4-Chlorophenyl)pyrrolidine-2-carboxylic acid hydrochloride CAS 2646-77-7
| CAS No. | 2646-77-7 |
| Molecular Formula | C11H12ClNO2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
5-(4-Chlorophenyl)pyrrolidine-2-carboxylic acid hydrochloride (CAS 2646-77-7) is a high-purity analytical reference standard with the molecular formula C11H12ClNO2HCl and a molecular weight of 262.13 g/mol.
The molecular framework of 5-(4-Chlorophenyl)pyrrolidine-2-carboxylic acid hydrochloride (C11H12ClNO2HCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H12ClNO2 HCl |
| Molecular Weight | 262.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chlorophenyl Standards
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- 1-(2-Chlorophenyl)-5-oxo-N-phenyl-2,5-dihydro-1H-1,2,4-triazole-3-carboxamide (CAS 1000577-29-6)
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Recommended Standards
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- 4,6-Dichlorobenzo[d]thiazol-2(3H)-one (CAS 87553-88-6)
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- L-Hercynine (CAS 534-30-5)
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- 4-(3-(Trifluoromethyl)pyridin-2-yl)-N-(5-(trifluoromethyl)pyridin-2-yl)piperazine-1-carboxamide (CAS 821768-06-3)
- 6-Chloro-2,8-dimethylquinoline (CAS 948289-20-1)
- MCH-Gene-Overprinted-Polypeptide-14 (rat) (H-4746.0500) (CAS 182917-44-8)
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