1-(5-Chloropyridin-2-yl)-3-(2-(4-ethoxy-3-fluoropyridin-2-yl)ethyl)thiourea CAS 265672-03-5
| CAS No. | 265672-03-5 |
| Molecular Formula | C18H17BrFN3O3 |
| Molecular Weight | 422.25 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 422.25 g/mol gives 1-(5-Chloropyridin-2-yl)-3-(2-(4-ethoxy-3-fluoropyridin-2-yl)ethyl)thiourea distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
1-(5-Chloropyridin-2-yl)-3-(2-(4-ethoxy-3-fluoropyridin-2-yl)ethyl)thiourea (CAS 265672-03-5) is a high-purity analytical reference standard with the molecular formula C18H17BrFN3O3 and a molecular weight of 422.25 g/mol.
1-(5-Chloropyridin-2-yl)-3-(2-(4-ethoxy-3-fluoropyridin-2-yl)ethyl)thiourea (C18H17BrFN3O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H17BrFN3O3 |
| Molecular Weight | 422.25 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 3 |
Related Chloropyridin Standards
- 1-((2-((2-Chloropyridin-4-yl)amino)-4'-(cyclopropylmethyl)-[4,5'-bipyrimidin]-2'-yl)amino)-2-methylpropan-2-ol (CAS 1383716-33-3)
- 2-(2-Chloropyridin-3-yl)-1-(2,4-dichlorobenzyl)-5,6-dimethyl-1H-benzo[d]imidazole (CAS 344279-04-5)
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- 2-(6-Chloropyridin-3-yl)-1-[(3,4-dichlorophenyl)methyl]-5,6-dimethyl-1H-1,3-benzodiazole (CAS 337920-65-7)
- 2-(2-Chloropyridin-3-yl)-5,6-dimethyl-1-{[3-(trifluoromethyl)phenyl]methyl}-1H-1,3-benzodiazole (CAS 339101-23-4)
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Recommended Standards
- 4-(2-Hydroxyethyl)-1-((4-iodophenyl)sulfonyl)-2,5-dimethyl-1,2-dihydro-3H-pyrazol-3-one (CAS 866039-54-5)
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- 3-Iodo-1-tosyl-1H-indole-5-carbonitrile (CAS 676273-39-5)
- 2-(5-Iodo-2-Methylbenzoyl)-5-(4-fluorophenyl)thiophene (CAS 1071929-08-2)
- 5-Bromo-2-chloro-4-(trifluoromethyl)aniline (CAS 1807043-08-8)
- 7-Bromo-6-chloro-1H-pyrrolo[3,2-c]pyridine (CAS 1956386-38-1)
- 2-(2,2-difluoroethoxy)pyridine-4-carbonitrile (CAS 1423028-75-4)
- (R)-4-((S)-1-Hydroxy-3-methoxypropyl)-1-((R)-1-(4-methoxyphenyl)ethyl)pyrrolidin-2-one (CAS 1650544-70-9)
- Edaravone Impurity 7 (CAS 1242471-40-4)
- N-MEthyl-6-piperidin-3-ylpyridine-2-carboxamide dihydrochloride (CAS 1858241-04-9)
- Benzyl oleate (CAS 55130-16-0)
- 3-methyl-1,2,4-thiadiazole-5-carboxylic acid;sodium salt (CAS 2231673-03-1)
- Tert-butyl n-[2-amino-1-(2-methoxyphenyl)ethyl]carbamate (CAS 1016696-47-1)
- Des-Tyr10-Tirzepatide (CAS CATO-CPTD788680)
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