(2Z)-2-[(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)methylidene]-2,3-dihydro-1H-inden-1-one CAS 268563-95-7
| CAS No. | 268563-95-7 |
| Molecular Formula | C22H14F3NO2 |
| Molecular Weight | 381.35 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (2Z)-2-[(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)methylidene]-2,3-dihydro-1H-inden-1-one.
(2Z)-2-[(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)methylidene]-2,3-dihydro-1H-inden-1-one (CAS 268563-95-7) is a high-purity analytical reference standard with the molecular formula C22H14F3NO2 and a molecular weight of 381.35 g/mol.
The molecular framework of (2Z)-2-[(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)methylidene]-2,3-dihydro-1H-inden-1-one (C22H14F3NO2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H14F3NO2 |
| Molecular Weight | 381.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
- 3-(3,5-Dimethyl-4-(3-(3-methylisoxazol-5-yl)propoxy)phenyl)-5-(trifluoromethyl)-1,2,4-oxadiazole (CAS 153168-05-9)
- Ethyl 2-(6-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetate (CAS 1052634-92-0)
- 1-(Isoxazolidin-2-yl)-2-(4-(4-(trifluoromethyl)phenoxy)phenoxy)propan-1-one (CAS 88081-63-4)
- 2-Phenyl-3-((4-(trifluoromethoxy)phenyl)amino)-1H-inden-1-one (CAS 1022801-36-0)
- 1-methylimidazo[4,5-b]pyridine (CAS 39998-52-2)
- [6-(2-ethoxyphenoxy)pyridin-3-yl]methanamine (CAS 954575-99-6)
- Methyl 2-formyl-3-methylbutanoate (CAS 20656-63-7)
- 3-Bromo-n-(2-biphenylyl)carbazole (CAS 1609267-04-0)
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- (7-Methyl-7-azaspiro[3.5]Nonan-2-yl)methanamine dihydrochloride (CAS 2306272-90-0)
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- Ethyl (3-(trifluoromethyl)phenyl)glycinate (CAS 2445-84-3)
- Peptide YY (3-36) (canine, mouse, porcine, rat) trifluoroacetate salt (CAS 126339-09-1)
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