2-Chloro-2-Fluoro-1-(4-Morpholinyl)Ethanone CAS 27074-60-8
| CAS No. | 27074-60-8 |
| Molecular Formula | C6H9ClFNO2 |
| Molecular Weight | 181.59 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-Chloro-2-Fluoro-1-(4-Morpholinyl)Ethanone is closely related to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2-Chloro-2-Fluoro-1-(4-Morpholinyl)Ethanone (CAS 27074-60-8) is a high-purity analytical reference standard with the molecular formula C6H9ClFNO2 and a molecular weight of 181.59 g/mol.
Structurally, 2-Chloro-2-Fluoro-1-(4-Morpholinyl)Ethanone (C6H9ClFNO2) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 2.0, corresponding to approximately 2 ring(s) or double-bond equivalent(s). With a molecular weight of 181.59 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H9ClFNO2 |
| Molecular Weight | 181.59 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
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- 2-Chloro-5-fluoroquinoline (CAS 455955-27-8)
- 3-(3-Carboxypropanamido)benzoic acid (CAS 259222-20-3)
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- Lanthanum(III) acetate hydrate (CAS 100587-90-4)
- 3-Methyl-4-(2-nitrophenyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-b]pyridin-6-one (CAS 442652-86-0)
- Ethyl α-amino-α-cyanoacetate (CAS 32683-02-6)
- Insulin Degludec Impurity 15 (CAS CATO-C4X-215715)
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