5-Chloro-2,6-difluoropyrimidin-4-amine CAS 27078-72-4
| CAS No. | 27078-72-4 |
| Molecular Formula | C4H2ClF2N3 |
| Molecular Weight | 165.53 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 5-Chloro-2,6-difluoropyrimidin-4-amine (CAS 27078-72-4), a certified reference material (molecular formula C4H2ClF2N3, MW 165.53 g/mol) for analytical method development and quality control.
Owing to a nitrile group, fluorine/chlorine substitution, 5-Chloro-2,6-difluoropyrimidin-4-amine is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 165.53 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C4H2ClF2N3 |
| Molecular Weight | 165.53 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- 5-Chloro-1-methyl-4-nitroimidazole-13C4 (CAS 1391052-79-1)
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Recommended Standards
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- Methanol, 1-[2-(triphenylmethyl)hydrazinyl]- (CAS 1956365-95-9)
- 1-(3,5-Difluorophenyl)cyclopropanemethanamine (CAS 1249615-63-1)
- (4-(Isopropoxycarbonyl)-2-nitrophenyl)boronic acid (CAS 1150114-61-6)
- L-GLUTAMINE (1-13C, 99%) (CAS 159663-16-8)
- Ethyl 4-(2-((6-(4-bromophenyl)-3-cyano-4-(trifluoromethyl)pyridin-2-yl)thio)acetamido)piperidine-1-carboxylate (CAS 625377-92-6)
- H-Abu-NH2 (CAS 7324-11-0)
- 2-(3-Bromo-2-methylphenyl)-5-(hydroxymethyl)benzo[d]oxazole-7-carbonitrile (CAS 2459479-72-0)
- trans,trans-4'-Pentyl-4-(3,4,5-trifluorophenyl)bicyclohexyl (CAS 137644-54-3)
- 2-Morpholinoquinazolin-4(3H)-one (CAS 33080-91-0)
- Neuropeptide W-23 (rat) (CAS 383415-89-2)
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