4,6-difluoro-5-nitropyrimidine CAS 2714-25-2
| CAS No. | 2714-25-2 |
| Molecular Formula | C4HF2N3O2 |
| Molecular Weight | 161.07 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 4,6-difluoro-5-nitropyrimidine (CAS 2714-25-2), a certified reference material (molecular formula C4HF2N3O2, MW 161.07 g/mol) for analytical method development and quality control.
Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, 4,6-difluoro-5-nitropyrimidine is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 161.07 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C4HF2N3O2 |
| Molecular Weight | 161.07 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related difluoro Standards
- 2,4-difluoro-5-nitropyrimidine (CAS 40858-82-0)
- methyl 3,4-difluoro-1H-pyrrole-2-carboxylate (CAS 160561-79-5)
- 5,6-Difluoro-3-methoxypyrazin-2-amine (CAS 55215-73-1)
- 4,4-Difluoro-1-hydroxycyclohexane-1-carbonitrile (CAS 1150617-90-5)
- 1,1-difluoro-4-isocyanato-cyclohexane (CAS 1246210-02-5)
- 5,5-Difluoro-3-methyl-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxazole (CAS 1823347-67-6)
- 1,1-Difluoro-3-(1H-imidazol-5-yl)propan-2-amine (CAS 70734-40-6)
- 2,2-Difluoro-4,4-Dimethyl-3-Oxopentanenitrile (CAS 219866-68-9)
Recommended Standards
- Patulin-13C7 (CAS 1353867-99-8)
- 4-Bromo-1-butanol-1,1,2,2,3,3,4,4-d8 (CAS 136091-68-4)
- 2-(Trifluoromethyl)furan-3-carbonitrile (CAS 1248559-84-3)
- 1,3-Dihydro-1-methyl-2H-imidazole-2-selone (CAS 157997-38-1)
- 4-Chloro-6-isopropylquinazoline (CAS 937669-71-1)
- N'-(2-(3-methyl-5-(trifluoromethyl)-1H-pyrazol-1-yl)thiazole-4-carbonyl)methanesulfonohydrazide (CAS 955966-50-4)
- N'-[(1E)-[2-(3,5-Dimethylphenoxy)phenyl]methylidene]-4-[(4-methylphenyl)methoxy]benzohydrazide (CAS 320423-59-4)
- 5-Hydroxy-2-methyl-1-oxo-1,2-dihydroisoquinoline-6-carboxylic acid (CAS 1783406-37-0)
- 4-(Trifluoromethyl)phenylethyl bromide (CAS 130365-87-6)
- 5-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)furan-2-carbonitrile (CAS 863868-52-4)
- Tert-butyl ((2r,3R,4r,5S)-4-(aminomethyl)cuban-1-yl)carbamate (CAS 2108646-71-3)
- 2-(Dimethylamino)-2-phenylacetonitrile hydrochloride (CAS 5537-53-1)
- N-Methyl-1,1,1-Trifluoro-2-propylsulfamoyl chloride (CAS 1389310-28-4)
- Peptide YY (canine, mouse, porcine, rat) trifluoroacetate salt (CAS 81858-94-8)
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