(S)-2-(3-Chloro-2-hydroxypropoxy)isoindoline-1,3-dione CAS 272447-40-2
| CAS No. | 272447-40-2 |
| Molecular Formula | C11H10ClNO4 |
| Molecular Weight | 255.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (S)-2-(3-Chloro-2-hydroxypropoxy)isoindoline-1,3-dione.
(S)-2-(3-Chloro-2-hydroxypropoxy)isoindoline-1,3-dione (CAS 272447-40-2) is a high-purity analytical reference standard with the molecular formula C11H10ClNO4 and a molecular weight of 255.65 g/mol.
The molecular framework of (S)-2-(3-Chloro-2-hydroxypropoxy)isoindoline-1,3-dione (C11H10ClNO4) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (S)-2-(3-Chloro-2-hydroxypropoxy)isoindoline-1,3-dione meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H10ClNO4 |
| Molecular Weight | 255.65 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
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- Semaglutide impurity 67 (CAS CATO-C4X-222667)
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