5-Chloro-3-(chloromethyl)-1H-indazole CAS 27328-69-4
| CAS No. | 27328-69-4 |
| Molecular Formula | C8H6Cl2N2 |
| Molecular Weight | 201.05 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5-Chloro-3-(chloromethyl)-1H-indazole (CAS 27328-69-4), molecular formula C8H6Cl2N2 and molecular weight 201.05 g/mol, is a CATO reference standard with documented purity and traceability.
5-Chloro-3-(chloromethyl)-1H-indazole (C8H6Cl2N2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-Chloro-3-(chloromethyl)-1H-indazole meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H6Cl2N2 |
| Molecular Weight | 201.05 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 7-Chloro-2-(chloromethyl)imidazo[1,2-a]pyridine (CAS 124168-59-8)
- 3-Chloro-3-(p-chlorophenyl)acrolein (CAS 14063-77-5)
- 6-Chloro-2-(chloromethyl)imidazo[1,2-a]pyridine (CAS 182181-25-5)
- 2-Chloro-4-ethenylbenzoyl chloride (CAS 1935415-61-4)
- (2Z)-3-Chloro-3-(4-chlorophenyl)prop-2-enal (CAS 88438-06-6)
- 3-Chloro-3-(4-chlorobenzyl)-3H-diazirine (CAS 91309-66-9)
- 5-Chloro-2-(chloromethyl)imidazo[1,2-a]pyridine (CAS 223567-62-2)
- 5-Chloro-2-chloromethyl-1H-benzoimidazole (CAS 20443-38-3)
Recommended Standards
- 6,7-Dichloro-2,3-dihydro-1H-inden-1-one (CAS 68755-30-6)
- 8-Chloro-2-(chloromethyl)imidazo[1,2-a]pyridine (CAS 885275-94-5)
- 5,7-Dichloro-2-methylbenzofuran (CAS 42969-85-7)
- Ethyl 2,2-dichloro-2-ethoxyacetate (CAS 6957-89-7)
- 4-(4-Chlorophenyl)tetrahydro-2h-thiopyran-4-carboxylic acid 1,1-dioxide (CAS 2490709-15-2)
- 4-(BEnzyloxy)-1-chloro-2-fluorobenzene (CAS 1511273-81-6)
- 3064AC 848080-39-7 C17H15F3N8O2S N-(6-((4,5-Dicyano-1-methyl-1H-imidazol-2-yl)diazenyl)-1-methyl-1,2,3,4-tetrahydroquinolin-7-yl)-1,1,1-trifluoromethanesulfonamide (CAS 848080-39-7)
- N-(1-Aminobutan-2-yl)-5-methylpyrazine-2-carboxamide (CAS 792907-21-2)
- 5-Fluoro-2-iodo-4-methoxyaniline (CAS 1423019-17-3)
- 4-[(2-Methylpentyl)oxy]-2-(trifluoromethyl)aniline (CAS 946741-10-2)
- N2,N2,1-Trimethyl-1H-benzo[d]imidazole-2,6-diamine (CAS 462649-03-2)
- 7'-Chloro-1',2,3,4',5,6-hexahydro-3'H-spiro[pyran-4,2'-quinoxalin]-3'-one (CAS 1546465-77-3)
- (S)-2-(Iodomethyl)-1,4-dioxane (CAS 861852-09-7)
- D-β-Asp15-Tirzepatide (CAS CATO-CPTD788930)
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