2-Cyano-3’-(trifluoromethyl)acetophenone CAS 27328-86-5
| CAS No. | 27328-86-5 |
| Molecular Formula | C10H6F3NO |
| Molecular Weight | 213.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Cyano-3’-(trifluoromethyl)acetophenone.
2-Cyano-3’-(trifluoromethyl)acetophenone (CAS 27328-86-5) is a high-purity analytical reference standard with the molecular formula C10H6F3NO and a molecular weight of 213.16 g/mol.
2-Cyano-3’-(trifluoromethyl)acetophenone (C10H6F3NO) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2-Cyano-3’-(trifluoromethyl)acetophenone meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H6F3NO |
| Molecular Weight | 213.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Cyano Standards
- N-Cyano-3-(trifluoromethyl)benzamidine (CAS 1053656-87-3)
- N-Cyano-4-(trifluoromethyl)benzamidine (CAS 685541-39-3)
- 4-Cyano-5-(difluoromethyl)-2-methyl-3-nitropyridine (CAS 1806982-20-6)
- 5-Cyano-2-(pyridin-4-yl)-1H-imidazole-4-carboxamide (CAS 51294-33-8)
- 4-(3-Cyano-2-fluorophenyl)phenol (CAS 1261951-45-4)
- 5-Cyano-3,4-dihydroxy-thiophene-2-carboxylic acid ethyl ester (CAS 79763-59-0)
- Ethyl 2-cyano-3,3-diethoxyprop-2-enoate (CAS 1146943-46-5)
- 2-Cyano-pentanedioic acid diethyl ester (CAS 7251-97-0)
Recommended Standards
- 2,2,2-Trifluoro-1-(1H-indol-2-yl)ethanone (CAS 228873-77-6)
- 2-Hydroxy-4-(trifluoromethyl)quinoline (CAS 25199-84-2)
- 2-(Trifluoromethyl)quinolin-8-ol (CAS 41192-80-7)
- 3-(TRIFLUOROMETHYL)QUINOLIN-2(1H)-ONE (CAS 25199-83-1)
- N-(2,5-dimethoxyphenyl)-3-(2-nitrophenoxy)thiophene-2-carboxamide (CAS 252027-02-4)
- Carbamic acid, [[(2,5-dihydro-2,3-dimethyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)amino]thioxomethyl]-, ethyl ester (CAS 90012-60-5)
- 2-hydroxycycloheptanone (CAS 4436-58-2)
- 2,5-Dibromo-3-phenylthiophene (CAS 19698-46-5)
- 3-((1H-Benzo[d]imidazol-2-yl)methyl)-5-propyl-1,2,4-oxadiazole (CAS 898440-01-2)
- (2S,4S,5R)-4,5-Dihydroxypiperidine-2-carboxylic acid hydrochloride (CAS 1429476-34-5)
- 1-Methyl-3-(2,3,4-trifluorophenyl)-1h-pyrazol-5-amine (CAS 1502556-35-5)
- 2-(2-Methyl-1-trifluoromethoxymethyl-propyl)-isoindole-1,3-dione (CAS 1408279-75-3)
- Quinoline-8-boronic acid pinacol ester, 97% (CAS 190788-62-6)
- Tirzepatide Impurity 50 (CAS CATO-C4X-324050)
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