3-Ethynyl-5-fluoro-1H-indole-2-carbaldehyde CAS 2757701-15-6
| CAS No. | 2757701-15-6 |
| Molecular Formula | C11H6FNO |
| Molecular Weight | 187.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 3-Ethynyl-5-fluoro-1H-indole-2-carbaldehyde (CAS 2757701-15-6), a certified reference material (molecular formula C11H6FNO, MW 187.17 g/mol) for analytical method development and quality control.
The molecular framework of 3-Ethynyl-5-fluoro-1H-indole-2-carbaldehyde (C11H6FNO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-Ethynyl-5-fluoro-1H-indole-2-carbaldehyde meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H6FNO |
| Molecular Weight | 187.17 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2002 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Ethynyl Standards
- 1-Ethyl-3-ethynyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine (CAS 1701440-55-2)
- 2-Ethynyl-5-(trifluoromethoxy)pyridine (CAS 1876428-02-2)
- 5-Ethynyl-2-(piperidin-1-yl)pyrimidine (CAS 1196156-92-9)
- 3-Ethynyl-N-isopropylbenzamide (CAS 1638638-00-2)
- 3-Ethynyl-6-(piperidin-1-yl)pyridazine (CAS 1708269-15-1)
- 3-Ethynyl-1-(methylsulfonyl)piperidine (CAS 959918-29-7)
- 4-Ethynyl-1-(methylsulfonyl)piperidine (CAS 959918-30-0)
- 3-Ethynyl-N-isopentylaniline (CAS 1019517-32-8)
Recommended Standards
- 2-Methyl-3-nitrothiophene-5-carboxylic Acid (CAS 36050-35-8)
- 3-Methylisothiazole-4,5-dicarboxylic acid (CAS 67048-61-7)
- 2-((1H-Imidazol-4-yl)methyl)-2-amino-3-fluoropropanoic acid (CAS 70050-43-0)
- 4,5-Difluoro-1,3-benzothiazol-2-ol (CAS 898748-75-9)
- (R)-2,2-dimethyl-1-(2,4,5-trifluorophenyl)propan-1-amine (CAS 1388126-37-1)
- 1-Phenyl-3-(thiophen-2-yl)-1H-pyrazole-4-carbaldehyde (CAS 210825-11-9)
- N-(3-(Benzo[d]oxazol-2-yl)phenyl)-2-phenoxypropanamide (CAS 905235-07-6)
- Sildenafil impurity 249 (CAS CATO-C4X-1128249)
- N-((1H-imidazol-2-yl)methyl)-1-(2-methoxyphenyl)methanamine (CAS 921123-66-2)
- p-Nitrophenyl 4,6-O-Isopropylidene-α-D-galactopyranoside (CAS 29781-31-5)
- Drotaverin Impurity 69 (CAS CATO-C4X-243569)
- Fezolinetant Impurity 15 (CAS CATO-C4X-327015)
- 2-(4-Ethoxyphenyl)propanenitrile (CAS 51558-05-5)
- Tau Peptide (294-305) (human) trifluoroacetate salt (CAS 1428135-29-8)
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