Terbutaline impurity 99 CAS 27628-05-3
| CAS No. | 27628-05-3 |
| Molecular Formula | C22H19BrO3 |
| Molecular Weight | 411.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Terbutaline impurity 99.
Terbutaline impurity 99 (CAS 27628-05-3) is a certified pharmaceutical impurity reference standard with the molecular formula C22H19BrO3 and a molecular weight of 411.29 g/mol.
Structurally, Terbutaline impurity 99 (C22H19BrO3) contains a steroid core, a hydroxyl group, an ether linkage, bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 13.0, corresponding to approximately 13 ring(s) or double-bond equivalent(s). With a molecular weight of 411.29 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H19BrO3 |
| Molecular Weight | 411.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | Br-containing |
Related Terbutaline Standards
- Terbutaline impurity 102 (CAS CATO-C4X-1183102)
- Terbutaline impurity 103 (CAS CATO-C4X-1183103)
- Terbutaline Impurity 34 (CAS 28924-18-7)
- Terbutaline Impurity 47 (CAS CATO-C4X-118347)
- Terbutaline impurity 97 (CAS CATO-C4X-118397)
- Terbutaline impurity 98 (CAS CATO-C4X-118398)
- Terbutaline Impurity 49 (CAS CATO-C4X-118349)
- Terbutaline impurity 96 (CAS CATO-C4X-118396)
Recommended Standards
- 2-((2-((2,4-Dichloro-5-isopropoxyphenyl)amino)-2-oxoethyl)sulfonyl)-N,N-dimethylacetamide (CAS 341964-68-9)
- 2-({[2,4-dichloro-5-(2-methoxyethoxy)phenyl]carbamoyl}methanesulfinyl)-N,N-dimethylacetamide (CAS 341965-02-4)
- 2-[5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-yl]-2-(4-methoxyphenyl)acetonitrile (CAS 478043-31-1)
- 2-{[(2,4-dichloro-5-methoxyphenyl)carbamoyl]methanesulfonyl}-N,N-diethylacetamide (CAS 341965-18-2)
- Vildagliptin Impurity 91 (CAS CATO-C4X-110091)
- Sertaconazole nitrate EP Impurity B (CAS 17512-61-7)
- Faropenem Impurity 25 (CAS CATO-C4X-128925)
- N-Nitrosoheptamethyleneimine (CAS 20917-49-1)
- Dicyclohexylamine (S)-2-((tert-butoxycarbonyl)amino)-3-(3,4-dihydroxyphenyl)propanoate (CAS 102838-86-8)
- 5-(3,6-Dihydro-2H-pyran-4-yl)-1H-indazole (CAS 885272-68-4)
- tert-Butyl 2-(aminomethyl)-4,4-dimethylpyrrolidine-1-carboxylate (CAS 1891273-38-3)
- 2-(5-Fluoro-2-methoxyphenyl)acetonitrile (CAS 501008-41-9)
- 5-Ethyl-2-methoxybenzenesulfonyl chloride (CAS 88040-88-4)
- Glucagon receptor antagonists-2 (CAS 202917-18-8)
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