Enalapril Maleate EP Impurity E CAS 2775292-20-9
| CAS No. | 2775292-20-9 |
| Molecular Formula | C26H32N2O5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Enalapril Maleate EP Impurity E.
Enalapril Maleate EP Impurity E (CAS 2775292-20-9) is a certified pharmaceutical impurity reference standard with the molecular formula C26H32N2O5C4H4O4 and a molecular weight of 568.62 g/mol.
The molecular framework of Enalapril Maleate EP Impurity E (C26H32N2O5C4H4O4) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Enalapril Maleate EP Impurity E meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C26H32N2O5 C4H4O4 |
| Molecular Weight | 568.62 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2003 |
| Nitrogen Atoms | 2 |
Related Enalapril Standards
- Enalapril tert-Butyl Ester (CAS 108428-39-3)
- Enalapril Maleate Impurity 26 (CAS 115623-21-7)
- Enalapril EP Impurity D (CAS 115729-52-7)
- Enalapril-d5 tert-Butyl Ester (CAS 1356837-84-7)
- Enalapril-d3DISCONTINUED. Please see E555258 and E555252 (CAS 1356847-94-3)
- Enalapril EP Impurity A Maleate (CAS 1356932-13-2)
- Enalapril Impurity 19 (CAS 15121-89-8)
- Enalapril Impurity N1 (CAS 17450-56-5)
Recommended Standards
- Celecoxib Impurity 37 (CAS 326-06-7)
- Faropenem Impurity 60 (CAS CATO-C4X-128960)
- Conjugated Estrogens Impurity 17 (CAS CATO-C4X-141617)
- 7-hydroxy aristolochic acid A (CAS 79185-75-4)
- 2-Chlorobicyclo[2.2.1]heptane-2-carboxylic acid (CAS 101774-57-6)
- NSC 23766 TriHCl (CAS 1177865-17-6)
- 1-Acetyl-4-hydroxy-6-indole carboxylic Acid ethyl ester (CAS 885519-06-2)
- 1-(Benzo[c][1,2,5]oxadiazol-5-yl)-N-methylmethanamine (CAS 915921-29-8)
- 2-Amino-N-(o-tolyl)acetamide (CAS 145133-90-0)
- Peptide 436 (CAS CATO-CPTD788436)
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